Calprotectin levels in patients with rheumatoid arthritis to assess and association with exercise treatment

Basit Öğe Kaydı
dc.authorscopusid56406174400
dc.authorscopusid23968920100
dc.authorscopusid37077994100
dc.authorscopusid42661653300
dc.authorscopusid57191926529
dc.authorscopusid16039232300
dc.authorscopusid44661297900
dc.contributor.authorAcar, Ayşe
dc.contributor.authorGüzel, Savaş
dc.contributor.authorSarıfakıo?lu, Ayşe Banu
dc.contributor.authorÇelik Güzel, Eda
dc.contributor.authorYıldırım Güzelant, Aliye
dc.contributor.authorKaradağ, Ceyda
dc.contributor.authorKızıler, Lebriz
dc.date.accessioned2022-05-11T14:10:04Z
dc.date.available2022-05-11T14:10:04Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalı
dc.description.abstractRheumatoid arthritis (RA) is a chronic, inflammatory, and autoimmune disease that can cause permanent joint damage. In our study, we aim to analyze the change in calprotectin levels following the low-density exercise levels applied to the patients with RA. Twenty-eight patients with RA and 30 healthy controls were included in this study. To evaluate the activity of disease in RA, scores of disease activity that has increased (DAS-28) are figured. Calprotectin, nitric oxide (NO), white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF) levels are tested as the laboratory evaluation. Calprotectin, NO, CRP, ESR, WBC, and RF levels were significantly higher in the patient group compared to the control group (p < 0.01, p < 0.001, p < 0.01, p < 0.01, p < 0.01, and p < 0.05, respectively). In correlation analysis applied to the patient group with RA, there has been determined a positive relation with calprotectin, and DAS-28, CRP, NO, RF, and WBC (p < 0.001, p < 0.05, p < 0.001, p < 0.05, and p < 0.05, respectively). In result of the low-density exercise treatment applied to patients with RA for 8 weeks, there has been determined a significant decrease in calprotectin, DAS-28, NO, CRP, ESR, and RF levels (p < 0.05, p < 0.001, p < 0.01, p < 0.05, p < 0.05, and p < 0.05, respectively). As a result, a significant relation is found between RA disease activity and calprotectin levels and other inflammatory parameters. At the same time, it shows that calprotectin which is a significant indicator of local inflammation can be used as a good identifier in following up exercise treatment.
dc.identifier.doi10.1007/s10067-016-3240-y
dc.identifier.endpage2692
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue11en_US
dc.identifier.pmid27094943
dc.identifier.scopus2-s2.0-84964334280
dc.identifier.scopusqualityQ2
dc.identifier.startpage2685
dc.identifier.urihttps://doi.org/10.1007/s10067-016-3240-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5270
dc.identifier.volume35
dc.identifier.wosWOS:000386362000008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAcar, Ayşe
dc.institutionauthorGüzel, Savaş
dc.institutionauthorSarıfakıo?lu, Ayşe Banu
dc.institutionauthorÇelik Güzel, Eda
dc.institutionauthorYıldırım Güzelant, Aliye
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofClinical Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCalprotectin
dc.subjectDisease activity
dc.subjectExercise treatment
dc.subjectNitric oxide
dc.subjectRheumatoid arthritis
dc.subjectC-Reactive Protein
dc.subjectDisease-Activity
dc.subjectNitric-Oxide
dc.subjectSynovial-Fluid
dc.subjectSerum-Levels
dc.subjectPlasma
dc.subjectInflammation
dc.subjectMuscle
dc.subjectMethotrexate
dc.subjectExpression
dc.titleCalprotectin levels in patients with rheumatoid arthritis to assess and association with exercise treatment
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5270.pdf
Boyut:
485.98 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu