Ebselen, an Active Seleno-Organic Compound, Alleviates Articular Cartilage Degeneration in a Rat Model of Knee Osteoarthritis

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dc.authoridKaçmaz, Filiz/0000-0002-7166-8265
dc.authoridOKUYAN, HAMZA MALIK/0000-0001-7616-3330
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorYurtal, Ziya
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorKaçmaz, Filiz
dc.contributor.authorKalacı, Aydıner
dc.date.accessioned2023-05-06T17:23:46Z
dc.date.available2023-05-06T17:23:46Z
dc.date.issued2022
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractOsteoarthritis (OA) is a prevalent articular disease mainly characterized by extracellular matrix degradation, apoptosis, and inflammation, which lead to cartilage destruction and abnormal bone metabolism. With undesirable side effects, current limited symptomatic treatments are aimed at relieving pain and improving joint mobility in patients with OA. Intra-articular (IA) hyaluronic acid (HA) injection, as a nonsurgical therapy, is commonly used in the clinical management of knee OA, but the efficacy of this therapeutic option remains controversial. Ebselen has tremendous pharmacological importance for some diseases due to its antioxidant, antiapoptotic, and anti-inflammatory features. However, there is no research examining the therapeutic effect of Ebselen in OA using the rat OA model. Therefore, we aimed to investigate the therapeutic effect of Ebselen on cartilage degeneration and its role in bone morphogenetic protein 2 (BMP2) and nuclear factor kappa B (NF-kappa B) signaling in the molecular pathogenesis of OA. We induced a knee OA model in rats with an IA injection of monosodiumiodoacetate (MIA). After the treatment of Ebselen, we evaluated its chondroprotective effects by morphological, histopathological, and immunohistochemical methods and an enzyme-linked immunosorbent assay. We report for the first time that Ebselen treatment alleviated articular cartilage degeneration in the rat knee OA model and reduced MIA-induced BMP2 and NF-kappa B expressions. In addition, our results unveiled that Ebselen decreased IL-beta and IL-6 levels but did not affect COMP levels in the rat serum. Ebselen could be a promising therapeutic drug for the prevention and treatment of OA by alleviating cartilage degeneration and regulating BMP2 and NF-kappa B expressions.
dc.description.sponsorshipScientific Research Project Fund of Hatay Mustafa Kemal University [19M047]
dc.description.sponsorshipThe present study is financially supported by the Scientific Research Project Fund of Hatay Mustafa Kemal University under project number: 19M047.
dc.identifier.doi10.1007/s12011-022-03472-4
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.pmid36357655
dc.identifier.scopus2-s2.0-85141693745
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s12011-022-03472-4
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12293
dc.identifier.wosWOS:000881601700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOsteoarthritis
dc.subjectEbselen
dc.subjectCartilage Degeneration
dc.subjectMonosodium iodoacetate
dc.subjectBMP2
dc.subjectNF-kappa B
dc.subjectSenescence
dc.subjectCytokines
dc.subjectSerum
dc.subjectBone
dc.titleEbselen, an Active Seleno-Organic Compound, Alleviates Articular Cartilage Degeneration in a Rat Model of Knee Osteoarthritis
dc.typeArticle

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