The relationship between copper, homocysteine and early vascular disease in lean women with polycystic ovary syndrome

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dc.authorid0000-0003-0810-6195
dc.authorscopusid24075279000
dc.authorscopusid55022842500
dc.authorscopusid6506061779
dc.authorscopusid6505680586
dc.authorscopusid42661653300
dc.authorscopusid8713588200
dc.authorscopusid7201896017
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidBastu, Ercan/K-5354-2017
dc.contributor.authorÇelik, Cem
dc.contributor.authorBastu, Ercan
dc.contributor.authorAbalı, Remzi
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorAydemir, Birsen
dc.contributor.authorYeh, John
dc.date.accessioned2022-05-11T14:15:42Z
dc.date.available2022-05-11T14:15:42Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Hemşirelik Bölümü
dc.description.abstractThis study investigates copper (Cu) levels and vascular dysfunction in lean women with polycystic ovary syndrome (PCOS). 44 subjects with PCOS, diagnosed according to Rotterdam criteria, and 42 healthy subjects matched for body mass index and age. Comparison of serum Cu, homocysteine, carotid intima-media thickness (CIMT), brachial artery flow mediated dilation (FMD) was carried out between PCOS patients and the control group. Clinical study was done in Namik Kemal University School of Medicine. The CIMT and concentration of Cu in PCOS patients was significantly higher than the healthy controls. FMD levels in PCOS patients were significantly lower than those in controls. In PCOS patients, CIMT was correlated with estrogen and Cu levels. However, FMD was correlated with age and Cu levels. Among these contributing factors, Cu levels were correlated with a change in CIMT and FMD. CIMT and FMD in PCOS patients were related to Cu levels as well as several cardiovascular risk factors. Thus, increased Cu levels may be responsible for the increased risk of early vascular disease in women with PCOS.
dc.identifier.doi10.3109/09513590.2013.774361
dc.identifier.endpage491
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue5en_US
dc.identifier.pmid23480818
dc.identifier.scopus2-s2.0-84875823349
dc.identifier.scopusqualityQ2
dc.identifier.startpage488
dc.identifier.urihttps://doi.org/10.3109/09513590.2013.774361
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6031
dc.identifier.volume29
dc.identifier.wosWOS:000316956300020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelik, Cem
dc.institutionauthorAbalı, Remzi
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBrachial artery flow mediated dilation
dc.subjectcarotid intima-media thickness
dc.subjectcopper
dc.subjecthomocysteine
dc.subjectpolycystic ovary syndrome
dc.subjectAtherosclerosis
dc.subjectEndothelium
dc.titleThe relationship between copper, homocysteine and early vascular disease in lean women with polycystic ovary syndrome
dc.typeArticle

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