Protective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats

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dc.authorid0000-0002-1393-3235
dc.authorid0000-0002-6683-5495
dc.authorscopusid6506514563
dc.authorscopusid17135573100
dc.authorscopusid6701637480
dc.authorscopusid6603136404
dc.authorscopusid6603048599
dc.authorscopusid6701808364
dc.authorwosidmeydan, Sedat/C-3366-2019
dc.contributor.authorZararsız, İsmail
dc.contributor.authorMeydan, Sedat
dc.contributor.authorSarsılmaz, Mustafa
dc.contributor.authorSongur, Ahmet
dc.contributor.authorÖzen, Oğuz Aslan
dc.contributor.authorSöğüt, Sadık
dc.date.accessioned2022-05-11T14:41:16Z
dc.date.available2022-05-11T14:41:16Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstractThis study aimed to investigate changes in the cerebellum of formaldehyde-exposed rats and the effects of omega-3 fatty acids on these changes. The study involved 21 male Wistar-Albino rats which were divided into three groups. The rats in Group I comprised the control group. The rats in Group II were injected with intraperitoneal 10% formaldehyde every other day. The rats in Group III received omega-3 fatty acids daily while exposed to formaldehyde. At the end of the 14-day experimental period, all rats were killed by decapitation and the cerebellum removed. The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), xanthine oxidase (XO), and malondialdehyde (MDA) levels were determined in cerebellum specimens by using spectrophotometric methods. In our study, levels of SOD and CAT were significantly decreased, and GSH-Px, XO, MDA levels were significantly increased in rats treated with formaldehyde compared with those of the controls. Whereas, it was seen that there was an increase in SOD and CAT enzyme activities and decrease in MDA, XO, and GSH-Px levels in rats administered to omega-3 fatty acids with exposure of formaldehyde. It was determined that exposure of formaldehyde increased free radicals in cerebellum of rats and this increase was prevented by administration of omega-3 fatty acids.
dc.identifier.doi10.1177/0748233710389852
dc.identifier.endpage495
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue6en_US
dc.identifier.pmid21444354
dc.identifier.scopus2-s2.0-79959801802
dc.identifier.scopusqualityQ3
dc.identifier.startpage489
dc.identifier.urihttps://doi.org/10.1177/0748233710389852
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9130
dc.identifier.volume27
dc.identifier.wosWOS:000292205200002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzen, Oğuz Aslan
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFormaldehyde
dc.subjectomega-3 fatty acids
dc.subjectcerebellum
dc.subjectrat
dc.subjectXanthine-Oxidase
dc.subjectHippocampus
dc.subjectExposure
dc.subjectCortex
dc.subjectBrain
dc.subjectToxicology
dc.subjectStress
dc.titleProtective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats
dc.typeArticle

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