Nondiyabetik obez kadınlarda hepatosteatoz ve insülin direnci arasındaki ilişki
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Dosyalar
Tarih
2008
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, normal glikoz toleranslı obez kadı n hastalarda ultrason ile saptanan karaciğer yağlanması ile insülin direnci arasındaki ilişkinin incelenmesi amaçlandı. Gereç ve Yöntemler: Çalışmaya beden kitle indeksi (BK‹) 30 ve üstü ultrasonografi ile karaciğer yağlanması saptanan 38 kadın hasta ve 14 sağlıklı kontrol alındı. Hastaların açlık kan şekeri, kolesterol, trigliserid, LDLkolesterol, HDL-kolesterol, insülin ve CRP düzeylerine bakıldı. Hastaların insülin direnci HOMA-IR (homeastasis model assement of insülin resistance) metodu ile saptandı. Bulgular: Hasta grubunda 2. saat kan şekeri, trigliserid, insülin, CRP ve HOMA-IR değerleri kontrol grubuna göre anlamlı derecede yüksek (sırasıyla; p<0,05, p<0,001, p<0,01, p<0,001, p<0,05) ve HDL-kolesterol düzeyi düşük bulundu (p<0,01). Çalışmaya alınan vakaları n HOMA-IR düzeyleri için 2,2 değeri insülin rezistansı varlığı için alt sınır olarak değerlendirildi. HOMAIR> 2,2 olan vakalarda HOMA-IR<2,2 olan vakalara göre trigliserid düzeyi anlamlı derecede yüksek saptandı (p<0,05). Ultrasonografik incelenme ile belirlenen yağ- lanma düzeyleri HOMA-IR>2,2 olan hastalarda daha yüksek bulundu. Sonuç: Sonuç olarak çalışmamızda obeziteden ba- ğımsız şekilde sadece insülin direncinin artışı bile hepatosteatoza yol açan bir etken olarak saptanmıştır. Glikoz toleransı normal olan obezlerde insülin rezistansı nın derecesi karaciğer yağlanmasının erken tanısında önemli bir belirteç olabileceği bulunmuştur.
Objectives: Hepatosteatosis is frequently seen in middle-aged women who mostly are obese and have insulin resistance. In this study, we investigated the relationship between hepatosteatosis detected on sonography and insulin resistance in obese women with normal glucose tolerance. Method: Thirthy eight patients and fourteen healthy people aged 30 and over were included in the study. A sonographic examination was performed to diagnose hepatosteatosis. Also, serum fasting glucose level, cholosterol, triglyceride, LDL- cholosterol and HDLcholosterol, insulin and CRP levels checked for the study. The insulin resistance in patients were detected by HOMA-IR method (homeastasis model assessment of insulin resistance). Results: In the patient group, serum glucose level at 2nd hour, triglyceride and insulin levels, CRP and HOMA- IR were significantly high (p<0,05, p<0,001, p<0,01, p<0,001, p<0,05, respectively) but HDL-cholosterol levels was low (p<0,01). The lower limit for HOMA-IR was determined as 2,2. Triglyceride level was significantly higher in patients with HOMA-IR>2,2 than in patients with HOMA-IR<2,2. The level of hepatosteatosis detected by sonography was higher in the patients with HOMA-IR level>2,2. Conclusion: It was shown that the increase in insulin resistance was the one of the reasons of hepatasteatoses even if obesity was considered as an independent factor. The level of insulin resistance triggerred hepatosteatosis in obese patients with normal glucose tolerance.
Objectives: Hepatosteatosis is frequently seen in middle-aged women who mostly are obese and have insulin resistance. In this study, we investigated the relationship between hepatosteatosis detected on sonography and insulin resistance in obese women with normal glucose tolerance. Method: Thirthy eight patients and fourteen healthy people aged 30 and over were included in the study. A sonographic examination was performed to diagnose hepatosteatosis. Also, serum fasting glucose level, cholosterol, triglyceride, LDL- cholosterol and HDLcholosterol, insulin and CRP levels checked for the study. The insulin resistance in patients were detected by HOMA-IR method (homeastasis model assessment of insulin resistance). Results: In the patient group, serum glucose level at 2nd hour, triglyceride and insulin levels, CRP and HOMA- IR were significantly high (p<0,05, p<0,001, p<0,01, p<0,001, p<0,05, respectively) but HDL-cholosterol levels was low (p<0,01). The lower limit for HOMA-IR was determined as 2,2. Triglyceride level was significantly higher in patients with HOMA-IR>2,2 than in patients with HOMA-IR<2,2. The level of hepatosteatosis detected by sonography was higher in the patients with HOMA-IR level>2,2. Conclusion: It was shown that the increase in insulin resistance was the one of the reasons of hepatasteatoses even if obesity was considered as an independent factor. The level of insulin resistance triggerred hepatosteatosis in obese patients with normal glucose tolerance.
Açıklama
Anahtar Kelimeler
Biyofizik, Endokrinoloji ve Metabolizma
Kaynak
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
48
Sayı
4
