VA Grubu halojenürlerin (MX3; M: Sb ve Bi, X: Cl, Br ve I) 2- imidazolidintiyon ile oluşturduğu bileşiklerin sentezi ve kimyasal yapılarının ayrıştırılması
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Dosyalar
Tarih
2018
Yazarlar
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Yayıncı
Namık Kemal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Metal içeren ilaçlar birkaç yüzyıldan bu yana kanser, diyabet ve romatizma gibi çe?itli hastalıkların tedavisinde yer almaktadır. VA grubunda bulunan elementlere ait inorganik ve organometalik bile?ikler, fiziksel özellikleri ve medikal i?levleri nedeniyle uzun zamandır tıp alanında kullanılmaktadır. Özellikle antimon ve bizmut bile?ikleri uzun yıllardan bu yana çe?itli hastalıkların tedavisinde oldukça önemli bir yere sahiptir. Gerçekle?tirilen bu tez çalı?masında kullanılan 2-imidazolidintiyonun da yer aldığı tiyoamid türevi ligandlar, koordinasyon kimyasında oldukça geni? bir kullanım alanına sahiptir. Ayrıca günümüzde tiyoamid türevi ligandların birçok ilacın etken maddesini olu?turduğu da bilinmektedir. Bu tez çalı?ması kapsamında 2-imidazolidintiyonun antimon (III) ve bizmut (III) halojenürler (SbX3, BiX3; X: Cl, Br ve I) ile olu?turduğu 6 adet yeni koordinasyon bile?iği sentezlenmi?tir. Sentezlenen bu yeni bile?iklerin kimyasal yapıları erime noktası, elementel analiz, molar iletkenlik, FT-IR spektroskopisi, FT-Raman spektroskopisi, termogravimetrik analiz, 1H ve 13C-NMR spektroskopisi yöntemleri ile aydınlatılmı?tır. 2-imidazolidintiyonun antimon (III) klorür, antimon (III) bromür, bizmut (III) klorür ve bizmut (III) bromür ile olu?turduğu reaksiyonlar 2:1 stokiyometrik oranlarda, antimon (III) iyodür ve bizmut (III) iyodür ile olu?turduğu reaksiyonlar ise 1:1 stokiyometrik oranlarda gerçekle?tirilmi?tir. [SbCl3(IMT)2], [SbBr3(IMT)2], [BiCl3(IMT)2] ve [BiBr3(IMT)2] bile?iklerinin kimyasal yapılarının kare piramit (SP) geometriye, [SbI3(IMT)] ve [BiI3(IMT)] bile?iğin kimyasal yapısının ise psödo trigonal bipiramit geometriye sahip olduğu belirlenmi?tir. Tüm monomerik yapıların antimon-halojenür ({[SbCl2(?2-Cl)(IMT)2]2}, {[SbBr2(?2-Br)(IMT)2]2} ve {[SbI2(?2-I)(IMT)2]n}) ve bizmut-halojenür ({[BiCl2(?2-Cl)(IMT)2]2, ({[BiBr2(?2-Br)(IMT)2]2 ve ({[BiI2(?2-I)(IMT)2]n) köprüleri sayesinde birbirine bağlanarak dimerik veya polimerik yapıları olu?turduğu tespit edilmi?tir.
Metal-based drugs have been used for various diseases such as cancer, diabetes and rheumatism since a few centuries. The VA main group metal compounds including inorganic and organometallic complexes have been studied in medicine for decades owing to the interesting physical properties and medical functions. Especially antimony and bismuth compounds have been very important in the treatment of various diseases since many years. The thioamide-derived ligands, including the 2-imidazolidinone used in this thesis study, have a wide range of applications in coordination chemistry. It is also known today that thioamide derivative ligands are the agents of many drugs. Within the scope of this thesis study six new coordination compounds have been synthesized with 2-imidazolidinone with antimony (III) and bismuth (III) halides (SbX3, BiX3, X: Cl, Br and I). The chemical structures of synthesized complexes have been characterized by melting point, molar conductivity, FT-IR spectroscopy, FT-Raman spectroscopy, 1H and 13C-NMR spectroscopy, TG-DTA analysis. Reactions of 2-imidazolidinethion with antimony (III) chloride, antimony (III) bromide, bismuth (III) chloride and bismuth (III) bromide reactions at 2: 1 stoichiometric ratios with antimony (III) iodide and bismuth (III) iodide 1: 1 stoichiometric ratios. The chemical structures of compounds [SbCl3(IMT)2], [SbBr3(IMT)2], [BiCl3(IMT)2] and [BiBr3(IMT)2] were found to have square pyramid (SP) geometry and the chemical structure of compound [SbI3(IMT)] and [BiI3(IMT)] had pseudo trigonal bipyramide geometry. All monomeric structures have been found to form dimeric or polymeric structures by bonding to each other through antimony-halide and bismuth-halide bridges.
Metal-based drugs have been used for various diseases such as cancer, diabetes and rheumatism since a few centuries. The VA main group metal compounds including inorganic and organometallic complexes have been studied in medicine for decades owing to the interesting physical properties and medical functions. Especially antimony and bismuth compounds have been very important in the treatment of various diseases since many years. The thioamide-derived ligands, including the 2-imidazolidinone used in this thesis study, have a wide range of applications in coordination chemistry. It is also known today that thioamide derivative ligands are the agents of many drugs. Within the scope of this thesis study six new coordination compounds have been synthesized with 2-imidazolidinone with antimony (III) and bismuth (III) halides (SbX3, BiX3, X: Cl, Br and I). The chemical structures of synthesized complexes have been characterized by melting point, molar conductivity, FT-IR spectroscopy, FT-Raman spectroscopy, 1H and 13C-NMR spectroscopy, TG-DTA analysis. Reactions of 2-imidazolidinethion with antimony (III) chloride, antimony (III) bromide, bismuth (III) chloride and bismuth (III) bromide reactions at 2: 1 stoichiometric ratios with antimony (III) iodide and bismuth (III) iodide 1: 1 stoichiometric ratios. The chemical structures of compounds [SbCl3(IMT)2], [SbBr3(IMT)2], [BiCl3(IMT)2] and [BiBr3(IMT)2] were found to have square pyramid (SP) geometry and the chemical structure of compound [SbI3(IMT)] and [BiI3(IMT)] had pseudo trigonal bipyramide geometry. All monomeric structures have been found to form dimeric or polymeric structures by bonding to each other through antimony-halide and bismuth-halide bridges.
Açıklama
Anahtar Kelimeler
Anorganik Kimya, Koordinasyon Kimyası, VA Grubu Halojenürler, 2-Imidazolidintiyon, Inorganic Chemistry, Coordination Chemistry, VA Group Halides, 2-Imidazolidinethione
