Tear Osmolarity and Ocular Surface Changes in Patient with Polycystic Ovary Syndrome

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dc.authorid0000-0002-6396-3168
dc.authorscopusid34869701000
dc.authorscopusid24075279000
dc.authorscopusid15844109600
dc.authorscopusid6506061779
dc.authorscopusid26655524000
dc.authorscopusid9733109900
dc.authorscopusid55314280200
dc.authorwosidKeskinbora, Kadircan/AAM-6453-2020
dc.authorwosidHorozoglu, Fatih/AAM-4273-2021
dc.contributor.authorGönen, Tansu
dc.contributor.authorÇelik, Cem
dc.contributor.authorÖznur, Meltem
dc.contributor.authorAbalı, Remzi
dc.contributor.authorGönen, Korcan Aysun
dc.contributor.authorHorozo?lu, Fatih
dc.contributor.authorKeskinbora, Kadircan Hıdır
dc.date.accessioned2022-05-11T14:10:01Z
dc.date.available2022-05-11T14:10:01Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Hemşirelik Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractPurpose: To evaluate the tear osmolarity and ocular surface changes in patients with polycystic ovary syndrome (PCOS). Materials and Methods: Forty-eight patients with recently diagnosed PCOS and thirty-three control volunteers were enrolled in this prospective, observational study. Ocular surface disease index (OSDI) score was calculated. Tear osmolarity was measured using the TearLab Osmolarity System (Tearlab, San Diego, CA, USA). All subjects also underwent the following ophthalmologic evaluation: Schirmer I test, tear-film breakup time (TBUT), ocular surface flourescein staining, and conjunctival impression cytology. Results: Mean OSDI score was significantly higher in patients with PCOS than control subjects (P = 0.001). Tear osmolarity was similar in both groups (P = 0.404). There were no significant differences between groups in Schirmer I test results, TBUT, and ocular surface flourescein staining scores (P > 0.05). Compared to control group, a statistically significant squamous metaplasia was observed in temporal bulbar conjunctival impression cytology specimens in PCOS group (P = 0.032). Conclusions: In patients with recently diagnosed PCOS, tear volume and osmolarity are not affected but, conjunctival morphology may be affected, though on a limited scale.
dc.description.sponsorshipScientific Research Projects Unit, University of Namik Kemal, Tekirdag, TurkeyNamik Kemal University
dc.description.sponsorshipThis research was supported in part by a grant from the Scientific Research Projects Unit, University of Namik Kemal, Tekirdag, Turkey. The authors are grateful to Gulnur Yenilmez, Pelin Toprakal Gok, and Halil Hanci for their assistance in this project. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
dc.identifier.doi10.3109/02713683.2012.749917
dc.identifier.endpage625
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue6en_US
dc.identifier.pmid23249394
dc.identifier.scopus2-s2.0-84877608120
dc.identifier.scopusqualityQ2
dc.identifier.startpage621
dc.identifier.urihttps://doi.org/10.3109/02713683.2012.749917
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5253
dc.identifier.volume38
dc.identifier.wosWOS:000318646600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGönen, Tansu
dc.institutionauthorÇelik, Cem
dc.institutionauthorÖznur, Meltem
dc.institutionauthorAbalı, Remzi
dc.institutionauthorGönen, Korcan Aysun
dc.institutionauthorHorozoğlu, Fatih
dc.institutionauthorKeskinbora, Kadircan Hıdır
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofCurrent Eye Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPolycystic ovary syndrome
dc.subjecttear osmolarity
dc.subjectconjunctival impression cytology
dc.subjectocular surface
dc.subjectdry eye
dc.subjectDry Eye
dc.subjectMeibomian Gland
dc.subjectDisease
dc.subjectPrevalence
dc.subjectWomen
dc.subjectHyperandrogenism
dc.subjectSecretion
dc.subjectFeatures
dc.subjectTests
dc.titleTear Osmolarity and Ocular Surface Changes in Patient with Polycystic Ovary Syndrome
dc.typeArticle

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