The effects of topical treatment with curcumin on burn wound healing in rats

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dc.authorscopusid10639223100
dc.authorscopusid24436194200
dc.authorscopusid8514414100
dc.authorscopusid26434076100
dc.authorscopusid7006356462
dc.authorscopusid36023238400
dc.authorscopusid14630077000
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorKulaç, Mustafa
dc.contributor.authorAktaş, Cevat
dc.contributor.authorTülübaş, Feti
dc.contributor.authorUygur, Ramazan
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorÖzen, Oğuz Aslan
dc.contributor.authorCeber, Mehmet
dc.contributor.authorTopçu, Birol
dc.date.accessioned2022-05-11T14:07:32Z
dc.date.available2022-05-11T14:07:32Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractThe present study was designed to determine the role of topical treatment with curcumin (Cur) on burn wound healing in rats. The Wistar-albino rats were randomly allotted into one of three experimental groups: 4th, 8th and 12th day (post burn) and all groups include subgroups which Burn and Burn + Cur. Each group contains 12 animals. Burn wounds were made on the back of rat and Cur was administered topically. At the end of the study, all animals were sacrificed and the wound tissues removed for analyse to biochemical and histopathological changes. There was a significant increase in the hydroxyproline levels in the skin of the Cur groups. Cur treated wounds were found to heal much faster as indicated by improved rates of inflammatory cells, collagen deposition, angiogenesis, granulation tissue formation and epithelialization which were also confirmed by histopathological and biochemical examinations. Our data also indicate that there is a rise in the expression of proliferating cell nuclear antigen in skin tissues of Cur-treated rats in the Burn group. The results clearly substantiate the beneficial effects of the topical application of Cur in the acceleration of wound healing.
dc.identifier.doi10.1007/s10735-012-9452-9
dc.identifier.endpage90
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue1en_US
dc.identifier.pmid23054142
dc.identifier.scopus2-s2.0-84872597381
dc.identifier.scopusqualityQ2
dc.identifier.startpage83
dc.identifier.urihttps://doi.org/10.1007/s10735-012-9452-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5137
dc.identifier.volume44
dc.identifier.wosWOS:000313495800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKulaç, Mustafa
dc.institutionauthorAktaş, Cevat
dc.institutionauthorTülübaş, Feti
dc.institutionauthorUygur, Ramazan
dc.institutionauthorCeber, Mehmet
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBurn wound healing
dc.subjectCurcumin
dc.subjectPCNA
dc.subjectHydroxyproline
dc.subjectRat
dc.subjectThermal-Injury
dc.subjectInduced Apoptosis
dc.subjectOxidative Damage
dc.subjectNitric-Oxide
dc.subjectSkin
dc.subjectRepair
dc.subjectLonga
dc.subjectCells
dc.subjectMice
dc.subjectHydroxyproline
dc.titleThe effects of topical treatment with curcumin on burn wound healing in rats
dc.typeArticle

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