Could the systemic immune-inflammation index be a predictor to estimate cerebrovascular events in hypertensive patients?

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dc.authorid0000-0003-4570-8339
dc.authorscopusid55754659100
dc.authorscopusid6505680586
dc.authorscopusid16315021800
dc.authorscopusid55317577700
dc.authorscopusid55754636400
dc.authorscopusid57207998379
dc.authorscopusid57223120339
dc.authorwosidGültekin, Ahmet/ABA-7274-2020
dc.contributor.authorAydın, Cihan
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorEmlek, Nadir
dc.contributor.authorŞahin, Ayhan
dc.contributor.authorAykac, Hüseyin
dc.date.accessioned2022-05-11T14:12:24Z
dc.date.available2022-05-11T14:12:24Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractBackground and objectives Hypertension is one of the most important risk factors for cardiovascular and cerebrovascular events. Inflammatory processes occupy an important place in the pathogenesis of hypertension. Many studies have studied inflammatory markers responsible for the onset of hypertension and organ damage. In this study, we investigated whether the systemic immune-inflammation index (SII) (platelet x neutrophil/lymphocyte), - one of the new inflammatory markers - can be used to predict cerebrovascular events in hypertensive patients. Methods Ambulatory blood pressure monitoring results between January 2019 and June 2020 of approximately 379 patients followed up with hypertension were retrospectively analyzed. These patients were divided into two groups as with or without a previous cerebrovascular event in the analyzed database. In all patients, complete blood count and biochemistry test results just before the cerebrovascular event were found from the database. SII, atherogenic index, neutrophil-lymphocyte ratio were calculated from the complete blood count. Forty-nine patients with stroke (group 1: 12.9%; mean age: 64.3 +/- 14.6) and 330 patients without stroke (group 2: 87.1%; mean age: 50.8 +/- 14.4). Results Ambulatory blood pressure measurements were lower in group 1. Lipid parameters were also lower in this group. Receiver operating characteristic curve analysis showed that SII had a sensitivity of 85.7% and specificity of 84.8 % for stroke in individuals who participated in the study when the cutoff value of SII was 633.26 x 10(3) (P = 0.0001) area under curve (95%); 0.898 (0.856-0.941). In multivariate logistic regression analysis, age and SII were significantly associated with a higher risk of stroke. Age, (hazard ratio:1.067; 95% CI, 1.021-1.115), SII (hazard ratio:1.009; 95% CI, 1.000-1.009), respectively. Conclusions In conclusion, SII is a simple, useful new inflammatory parameter for predicting stroke from hypertension. We found that the high SII levels increase the risk of stroke in hypertensive patients.
dc.identifier.doi10.1097/MBP.0000000000000560
dc.identifier.endpage38
dc.identifier.issn1359-5237
dc.identifier.issn1473-5725
dc.identifier.issue1en_US
dc.identifier.pmid34992205
dc.identifier.scopus2-s2.0-85123269343
dc.identifier.scopusqualityQ2
dc.identifier.startpage33
dc.identifier.urihttps://doi.org/10.1097/MBP.0000000000000560
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5543
dc.identifier.volume27
dc.identifier.wosWOS:000739843400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Cihan
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorŞahin, Ayhan
dc.institutionauthorAykac, Hüseyin
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofBlood Pressure Monitoring
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectblood pressure monitoring
dc.subjecthypertension
dc.subjectneutrophil
dc.subjectlymphocyte ratio
dc.subjectsystemic immune-inflammation index
dc.subjectExperimental Stroke
dc.subjectExpression
dc.subjectAtherosclerosis
dc.subjectNeutrophil
dc.subjectActivation
dc.subjectCells
dc.titleCould the systemic immune-inflammation index be a predictor to estimate cerebrovascular events in hypertensive patients?
dc.typeArticle

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