Does hyperbaric oxygen therapy reduce the effects of ischemia on colonic anastomosis in laparoscopic colon resection?

dc.authorid0000-0003-2006-9198
dc.authorscopusid17433815200
dc.authorscopusid8204207500
dc.authorscopusid35410250800
dc.authorscopusid55624501100
dc.authorscopusid56615123900
dc.authorscopusid23666445200
dc.authorscopusid23968920100
dc.authorwosidGurdal, Sibel Ozkan/ABA-3882-2020
dc.authorwosidSözen, Selim/ABA-6337-2020
dc.contributor.authorEmir, Seyfi
dc.contributor.authorGürdal, Sibel Özkan
dc.contributor.authorSözen, Selim
dc.contributor.authorBali, İlhan
dc.contributor.authorYeşildağ, Ebru
dc.contributor.authorÇelik, Atilla
dc.contributor.authorTopçu, Birol
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:09:55Z
dc.date.available2022-05-11T14:09:55Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Çocuk Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractBACKGROUND: An increase in intra-abdominal pressure causes a decrease in the splanchnic blood flow and the intramucosal pH of the bowel, as well as increasing the risk of ischemia in the colon. The aim of the present study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on the ischemia caused by laparoscopy in colonic anastomosis in an experimental model of laparoscopic colonic surgery. MATERIALS AND METHODS: We divided 30 male Wistar albino rats into three groups: Group A was the control (open colon anastomosis); Group B received LCA (laparoscopic colon anastomosis); while Group C received both LCA. and HBOT. Each group contained ten animals. We placed Group C (LCA and HBOT) in an experimental hyperbaric chamber into which we administered pure oxygen at 2.1 atmospheres absolute 100% oxygen for 60 min for ten consecutive days. RESULTS: The anastomotic bursting pressure value was found to be higher in the open surgery group (226 +/- 8.8) (Group A). The result for Group C (213 +/- 27), which received HBOT, was better than that for Group B (197 +/- 27). However, there was no statistically significant difference between Group B and Group C. Group A showed better healing than the other groups, while significant differences in the fibroblast proliferation scores were found between Groups A and B. In terms of tissue hydroxyproline levels, a significant difference was found between Groups A and B and between Groups A and C, but not between Groups B and C. CONCLUSIONS: HBOT increases the oxygen level in the injured tissue. Although HBOT might offer several advantages, it had only a limited effect on the healing of colonic anastomosis in rats with increased intra-abdominal pressure in our study.
dc.identifier.endpage90
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue1en_US
dc.identifier.pmid27026260
dc.identifier.scopus2-s2.0-84983390425
dc.identifier.scopusqualityQ3
dc.identifier.startpage83
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5196
dc.identifier.volume87
dc.identifier.wosWOS:000376226900017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEmir, Seyfi
dc.institutionauthorGürdal, Sibel Özkan
dc.institutionauthorSözen, Selim
dc.institutionauthorBali, İlhan
dc.institutionauthorYeşildağ, Ebru
dc.institutionauthorTopçu, Birol
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherEdizioni Luigi Pozzi
dc.relation.ispartofAnnali Italiani Di Chirurgia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnastomosis
dc.subjectColon
dc.subjectHyperbaric Oxygen Treatment
dc.subjectOxidative Stress
dc.subjectOxidative Stress
dc.subjectCarbon-Dioxide
dc.subjectInsufflation
dc.subjectTissue
dc.subjectStimulation
dc.subjectColectomy
dc.subjectSurgery
dc.subjectCancer
dc.subjectOxide
dc.titleDoes hyperbaric oxygen therapy reduce the effects of ischemia on colonic anastomosis in laparoscopic colon resection?
dc.typeArticle

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