The effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients

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dc.authorid0000-0002-9685-4486
dc.authorid0000-0002-8087-9654
dc.authorid0000-0003-2112-4056
dc.authorscopusid56611865100
dc.authorscopusid55560501800
dc.authorscopusid24463634000
dc.authorscopusid56715752200
dc.authorscopusid57190815558
dc.authorscopusid35616254600
dc.authorwosidersoy, ugur/X-7075-2018
dc.authorwosidsertbas, yasar/AAC-8155-2021
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.contributor.authorSertbaş, Yaşar
dc.contributor.authorSertbaş, Meltem
dc.contributor.authorErsoy, Uğur
dc.contributor.authorBilir, Bülent
dc.contributor.authorGünaydın, Seracettin
dc.contributor.authorÖzdemir, Ali
dc.date.accessioned2022-05-11T14:39:55Z
dc.date.available2022-05-11T14:39:55Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: To investigate the effect of ezetimibe on platelet functions as a drug which increases mevalonate levels. Methods: This retrospective study was conducted in Istanbul, Turkey, and comprised record of normolipidaemic and hyperlipidaemic patients taken from the outpatient clinic from October 2004 to February 2015,. The results were taken from the baseline and third-month data of ezetimibe treatment. SPSS 22 was used for statistical analysis. Results: Of the total, there were 50(53%) normolipidaemic patients and 45(47%) hyperlipidaemic ones. Pre- and post-treatment values ofmean platelet volume were significantly higher in the hyperlipidaemic group than controls (p < 0.001). In the hyperlipidaemic group there was no significant difference between pre- and post-treatment values of mean platelet volume (8.96 +/- 0.93 vs. 8.92 +/- 0.84; p > 0.05). Conclusion: The use of ezetimibe alone should not be the first choice in hyperlipidaemia treatment.
dc.identifier.endpage1561
dc.identifier.issn0030-9982
dc.identifier.issue12en_US
dc.identifier.pmid27924965
dc.identifier.scopus2-s2.0-84995578361
dc.identifier.scopusqualityQ4
dc.identifier.startpage1559
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8794
dc.identifier.volume66
dc.identifier.wosWOS:000388621700011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBilir, Bülent
dc.language.isoen
dc.publisherPakistan Medical Assoc
dc.relation.ispartofJournal of the Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEzetimibe
dc.subjectMean platelet volume
dc.subjectPlatelet activation
dc.subjectCoa-Reductase Inhibitor
dc.subjectCoronary-Heart-Disease
dc.subjectC-Reactive Protein
dc.subjectEndothelial Function
dc.subjectSimvastatin
dc.subjectHypercholesterolemia
dc.subjectPravastatin
dc.subjectMarkers
dc.subjectStatins
dc.titleThe effect of ezetimibe monotheraphy on mean platelet volume in patients with hyperlipidaemia: a retrospective study of 45 patients
dc.typeArticle

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