Cardioprotective effect of caffeic acid phenethyl ester on cardiac contusion following blunt chest trauma in rats

Basit Öğe Kaydı
dc.authorscopusid57208033518
dc.authorscopusid55838809000
dc.authorscopusid26434143900
dc.authorscopusid23968920100
dc.authorscopusid56659422100
dc.contributor.authorBıçakçı, N.
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorDökmeci, Ayşe Handan
dc.contributor.authorGüzel, S.
dc.contributor.authorFidanol Erboğa, Z.
dc.date.accessioned2022-05-11T14:02:43Z
dc.date.available2022-05-11T14:02:43Z
dc.date.issued2019
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractWe investigated the effects of caffeic acid phenethyl ester (CAPE) on cardiac damage after blunt chest injury. Forty male adult Wistar albino rats were divided into four groups; control, cardiac contusion, cardiac contusion + CAPE, and CAPE. CAPE, 10 mmol/kg, was administered intraperitoneally for 7 days following cardiac contusion. Heart tissue and blood were obtained at the end of the experimental period. Cardiac histopathology was determined using hematoxylin & eosin (H & E) staining. Expression of tumor necrosis factor-alpha (TNF-?) in cardiomyocytes was determined using immunohistochemistry. Cardiac apoptosis was determined using the TUNEL method. Serum creatine kinase (CK), creatine kinase-muscle/brain (CK-MB) and lactate dehydrogenase (LDH) levels were determined using spectrophotometric methods. The serum cardiac troponin I (C-TI) level was measured using the ELISA method. Myofibril loss was detected in the cardiomyocytes of the cardiac contusion group. Increased apoptosis and TNF-? expression were observed in the cardiac contusion group compared to the control group. Increased CK, CK-MB, LDH and C-TI levels were found in the cardiac contusion group. We found that CAPE administration improved myocardial function. Compared to the cardiac contusion group, CK, CK-MB, LDH and C-TI levels decreased significantly in the cardiac contusion + CAPE group. Administration of CAPE significantly inhibited apoptosis and cardiac TNF-? expression. Our findings demonstrate the therapeutic effects of CAPE for cardiac contusion damage after blunt chest trauma. © 2019, © 2019 The Biological Stain Commission.
dc.description.sponsorship18,16
dc.description.sponsorshipOur study was supported by Tekirdag Nam?k Kemal University, Scientific Research Projects Commission, Project number; NKUBAP.23.GA.18.160.
dc.description.sponsorshipOur study was supported by Tekirdag Namık Kemal University, Scientific Research Projects Commission, Project number; NKUBAP.23.GA.18.160.
dc.identifier.doi10.1080/10520295.2019.1586999
dc.identifier.endpage448
dc.identifier.issn1052-0295
dc.identifier.issue6en_US
dc.identifier.pmid30929510
dc.identifier.scopus2-s2.0-85063644853
dc.identifier.scopusqualityQ2
dc.identifier.startpage442
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1586999
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4453
dc.identifier.volume94
dc.identifier.wosWOS:000483618700008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBıçakçı, N.
dc.institutionauthorKaraboğa, İhsan
dc.institutionauthorDökmeci, Ayşe Handan
dc.institutionauthorGüzel, S.
dc.institutionauthorFidanol Erboğa, Z.
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectcaffeic acid phenethyl ester
dc.subjectcardiac contusion
dc.subjectcontusion
dc.subjectrats
dc.subjectTNF-?
dc.subjecttroponin - I
dc.subjectantioxidant
dc.subjectcaffeic acid derivative
dc.subjectcaffeic acid phenethyl ester
dc.subjectphenethyl alcohol
dc.subjectanimal
dc.subjectapoptosis
dc.subjectblunt trauma
dc.subjectcardiac muscle
dc.subjectdrug effect
dc.subjectheart
dc.subjectheart contusion
dc.subjectmale
dc.subjectmetabolism
dc.subjectthorax injury
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectApoptosis
dc.subjectCaffeic Acids
dc.subjectHeart
dc.subjectMale
dc.subjectMyocardial Contusions
dc.subjectMyocardium
dc.subjectPhenylethyl Alcohol
dc.subjectRats, Wistar
dc.subjectThoracic Injuries
dc.subjectWounds, Nonpenetrating
dc.titleCardioprotective effect of caffeic acid phenethyl ester on cardiac contusion following blunt chest trauma in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4453.pdf
Boyut:
7.08 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Sağlık Yüksekokulu Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu