Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity in clinical follow-up of patients with acute pancreatitis, with particular emphasis on oxidative stress parameters and lipid profile: a prospective pilot trial

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dc.authorid0000-0002-1347-8498
dc.authorid0000-0003-0375-1881
dc.authorid0000-0003-4056-4874
dc.authorid0000-0002-5694-3628
dc.authorid0000-0003-3540-3822
dc.authorscopusid56523201700
dc.authorscopusid57225339592
dc.authorscopusid57207987244
dc.authorscopusid54389224500
dc.authorscopusid7004285751
dc.authorscopusid6508166517
dc.authorscopusid12795911100
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorYüksekdağ, Sema
dc.contributor.authorYüksel, Esra
dc.contributor.authorTopçu, Ahmet
dc.contributor.authorKaraağaç, Neslihan
dc.contributor.authorUzun, Hafize
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorÜnal, Ethem
dc.date.accessioned2022-05-11T14:41:21Z
dc.date.available2022-05-11T14:41:21Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractThe purpose of this study was to investigate the possible role of PON-1, an antioxidant lipophilic enzyme linked to HDL-C (high-density lipoprotein cholesterol), on the pathophysiology and clinical follow-up of acute pancreatitis. Biochemical tests, PON-1 and oxidative stress parameters (malonyl dialdehyde, MDA; superoxide dismutase, SOD; total antioxidant capacity, TAC) were evaluated in the sera of patients with acute pancreatitis at admission (day 0), day 3 and day 10 of follow-up, between June and September 2017. SPSS 13.0 statistical software package programme was used for statistical analyses.Mean age was 51.4 of the total 25 patients. Ranson scores were 0-1 points (60%), 3-4 points (24%) and 5-6 points (16%). CTSI (computed tomography severity index) scores were calculated, and most of the patients were seen to have mild or average pancreatitis (96%). While total cholesterol, triacylglycerol and LDL-C (low-density lipoprotein) levels stayed in their normal limits, there was a significant decrement tendency. HDL-C level was seen to rise significantly above its upper limit at day 10 (p < 0.001). Mean PON-1 levels were measured as 69.23, 76.72 vs. 113.15 U/mL at days 0, 3 and 10, respectively; and it was positively correlated with HDL-C (p < 0.001). Serum SOD increased also in parallel with PON-1 (20.49 vs. 39.46 U/mL) while MDA level decreased significantly (3.9 vs. 2.28 mu M, p < 0.001). TAC was seen to rise significantly after treatment (0.52 vs. 1.22 mM). In conclusion, decreased PON-1 and HDL-C together with antioxidants SOD and TAC at the early period of acute pancreatitis were seen to rise after treatment, while the previously higher MDA level decreased in parallel. This reveals the importance of the balance between oxidative stress and antioxidant defense mechanisms in clinical progression of the disease, and the potential of PON-1 as a promising clinical marker.
dc.identifier.doi10.1080/19932820.2019.1595955
dc.identifier.issn1993-2820
dc.identifier.issn1819-6357
dc.identifier.issue1en_US
dc.identifier.pmid30914000
dc.identifier.scopus2-s2.0-85063508825
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1080/19932820.2019.1595955
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9157
dc.identifier.volume14
dc.identifier.wosWOS:000462508700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKızıler, Ali Rıza
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofLibyan Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute pancreatitis
dc.subjectparaoxonase (PON-1)
dc.subjectoxidative stress
dc.subjectmalonyl dialdehyde (MDA)
dc.subjectsuperoxid dismutase (SOD)
dc.subjecttotal antioxidant capacity (TAC)
dc.subjectlipid profile
dc.subjectSeverity
dc.subjectRelevant
dc.subjectRats
dc.titleSerum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity in clinical follow-up of patients with acute pancreatitis, with particular emphasis on oxidative stress parameters and lipid profile: a prospective pilot trial
dc.typeArticle

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