The effect of papaverine on tendon healing and adhesion in rats following Achilles tendon repair

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dc.contributor.authorCan, Erdem
dc.contributor.authorDincel, Yasar Mahsut
dc.contributor.authorKarabulut, Derya
dc.contributor.authorKarabağ, Sevil
dc.contributor.authorArslan, Yunus Ziya
dc.date.accessioned2024-10-29T17:55:23Z
dc.date.available2024-10-29T17:55:23Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectives: The study aimed to examine the histopathological and biomechanical effects of papaverine administered intraperitoneally and locally on Achilles tendon healing in a rat model. Materials and methods: Forty-eight adult male Sprague- Dawley rats (range, 300 to 400 g) were used in this study conducted between October and November 2022. The rats were divided into three groups, with each group further subdivided into two for sacrifice on either the 15th (early period) or 30th (late period) day after surgery. The first (control) group received no treatment following Achilles tendon repair, while papaverine was intraperitoneally administered every other day for 10 days in the second group and locally in the third group after surgery. On the 15th and 30th days, the rats were sacrificed, and their Achilles tendons were subjected to biomechanical testing and histopathological evaluation. Results: Histopathologically, there were no significant differences among the groups on the 15th day. However, on the 30th day, the locally applied papaverine group exhibited superior histopathological outcomes compared to the control group (p<0.05). Concerning the highest tensile strength values before rupture, the biomechanical assessment showed that the group receiving local papaverine treatment in the early period and both the group with systemic papaverine treatment and the one with local papaverine treatment in the late period displayed a statistically significant advantage compared to the control group (p<0.05). Conclusion: Locally administered papaverine has positive biomechanical effects in the early period and exhibits a positive correlation both histopathologically and biomechanically in the late period. Novel therapeutic options may be provided for patients through these findings.
dc.identifier.endpage376
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue2en_US
dc.identifier.startpage368
dc.identifier.trdizinid1257542
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1257542
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14000
dc.identifier.volume35
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJoint diseases and related surgery
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe effect of papaverine on tendon healing and adhesion in rats following Achilles tendon repair
dc.typeArticle

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