Evaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: Periostin may be associated with the Wnt pathway

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dc.authorid0000-0001-6266-2454
dc.authorid0000-0002-3734-1242
dc.authorscopusid57208486786
dc.authorscopusid57210139343
dc.authorscopusid6505844019
dc.authorscopusid15762370000
dc.authorscopusid56495083200
dc.authorscopusid55905821400
dc.authorscopusid57211511118
dc.authorwosidUslu, Sadettin/ABE-8560-2020
dc.contributor.authorSolmaz, Dilek
dc.contributor.authorUslu, Sadettin
dc.contributor.authorKozacı, Didem
dc.contributor.authorKaraca, Neslihan
dc.contributor.authorBülbül, Hale
dc.contributor.authorTarhan, Emine Figen
dc.contributor.authorAkar, Servet
dc.date.accessioned2022-05-11T14:39:56Z
dc.date.available2022-05-11T14:39:56Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Periostin has been shown to be involved in bone anabolism through the regulation of Wnt-beta-catenin signaling. It may be one of the pathogenic mechanisms in syndesmophyte formation in ankylosing spondylitis (AS). The aim of this study was to evaluate serum periostin levels in patients with AS and to assess relationships among biomarkers of bone formation and periostin in disease outcomes, particularly radiographic changes. Methods: Ninety-seven consecutive AS patients (78% male) and 48 healthy controls (75% male) were included in the study. Serum periostin, dickkopf-1 (DKK-1), sclerostin and vascular endothelial growth factor (VEGF) levels were measured using commercially available enzyme-linked immunosorbent assay kits. Disease-related characteristics of patients were assessed using Ankylosing spondylitis disease activity score - C-reactive protein (ASDAS-CRP), Bath AS Disease Activity Index, Bath AS Functional Index and Bath AS metrology index. Radiographs were scored using the modified New York criteria and modified Stokes AS spinal score (mSASSS). Results: Compared with control subjects, patients with AS had significantly lower serum levels of periostin (P < 0.001) and sclerostin (P < 0.001), but higher serum levels of VEGF (P < 0.001) and high-sensitivity CRP (P < 0.001). Serum periostin (P = 0.005) and sclerostin levels (P = 0.016) were significantly lower in patients with very high disease activity according to ASDAS-CRP. Current age (P = 0.009), age at symptom onset (P = 0.021) and hip joint involvement (P = 0.012) were independently associated with the development of syndesmophyte, in contrast to biomarkers of bone metabolism that we evaluated. Conclusion: Our results suggest that periostin is down-regulated in AS patients with highly active disease and may contribute to disease pathogenesis through an interaction with Wnt signaling.
dc.identifier.doi10.1111/1756-185X.13186
dc.identifier.endpage509
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue2en_US
dc.identifier.pmid28941122
dc.identifier.scopus2-s2.0-85030232455
dc.identifier.scopusqualityQ3
dc.identifier.startpage502
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13186
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8802
dc.identifier.volume21
dc.identifier.wosWOS:000423817900017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSolmaz, Dilek
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Rheumatic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectspondyloarthritis
dc.subjectoutcome measures
dc.subjectankylosing spondylitis
dc.subjectPOSTN protein
dc.subjectWnt signaling pathway
dc.subjectGiant-Cell Arteritis
dc.subjectErythrocyte Sedimentation-Rate
dc.subjectPolymyalgia-Rheumatica
dc.subjectClassification Criteria
dc.subjectNorthwestern Spain
dc.subjectOlmsted County
dc.subjectFollow-Up
dc.subjectManagement
dc.subjectMinnesota
dc.subjectSpectrum
dc.titleEvaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: Periostin may be associated with the Wnt pathway
dc.typeArticle

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