Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy

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dc.authoridIncesu, Alper/0000-0003-4404-4331
dc.authoridKaya, Mehmet/0000-0001-9710-2254
dc.authoridHuang, Yan/0000-0002-6315-5224
dc.authoridCETIN, YUKSEL/0000-0001-5101-3870
dc.contributor.authorKarakurt, Eyyup Murat
dc.contributor.authorCetin, Yuksel
dc.contributor.authorIncesu, Alper
dc.contributor.authorDemirtas, Huseyin
dc.contributor.authorKaya, Mehmet
dc.contributor.authorYildizhan, Yasemin
dc.contributor.authorTosun, Merve
dc.date.accessioned2024-10-29T17:59:23Z
dc.date.available2024-10-29T17:59:23Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThis study investigated the microstructures, mechanical performances, corrosion resistances, and in vitro studies of porous Ti-xNb-10Zr (x: 10 and 20; at. %) alloys. The alloys were fabricated by powder metallurgy with two categories of porosities, i.e., 21-25% and 50-56%, respectively. The space holder technique was employed to generate the high porosities. Microstructural analysis was performed by using various methods including scanning electron microscopy, energy dispersive spectroscopy, electron backscatter diffraction, and x-ray diffraction. Corrosion resistance was assessed via electrochemical polarisation tests, while mechanical behavior was determined by uniaxial compressive tests. In vitro studies, such as cell viability and proliferation, adhesion potential, and genotoxicity, were examined by performing an MTT assay, fibronectin adsorption, and plasmid-DNA interaction assay. Experimental results showed that the alloys had a dual-phase microstructure composed of finely dispersed acicular hcp & alpha;-Ti needles in the bcc & beta;-Ti matrix. The ultimate compressive strength ranged from 1019 MPa to 767 MPa for alloys with 21-25% porosities and from 173 MPa to 78 MPa for alloys with 50-56% porosities. Noted that adding a space holder agent played a more critical role in the mechanical behaviors of the alloys compared to adding niobium. The pores were largely open and exhibited irregular shapes, with uniform size distribution, allowing for cell ingrowth. Histological analysis showed that the alloys studied met the biocompatibility criteria required for orthopaedic biomaterial use.
dc.description.sponsorshipEPSRC Future LiME Hub [EP/N007638/1]; Republic of Turkey Ministry of National Education
dc.description.sponsorshipThe EPSRC Future LiME Hub (EP/N007638/1); PhD studentship, the Republic of Turkey Ministry of National Education.
dc.identifier.doi10.3390/ma16124240
dc.identifier.issn1996-1944
dc.identifier.issue12en_US
dc.identifier.pmid37374426
dc.identifier.scopus2-s2.0-85163837944
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/ma16124240
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14721
dc.identifier.volume16
dc.identifier.wosWOS:001017428300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpowder metallurgy
dc.subjectporosity
dc.subjectspace holder technique
dc.subjectcorrosion resistance
dc.subjectbiocompability
dc.titleMicrostructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy
dc.typeArticle

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