May the level and ratio changes of trace elements be utilized in identification of disease progression and grade in prostatic cancer?

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dc.authorscopusid6508166517
dc.authorscopusid8713588200
dc.authorscopusid23968920100
dc.authorscopusid55979457200
dc.authorscopusid6602449225
dc.authorscopusid36629395600
dc.authorscopusid7006833103
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorAydemir, Birsen
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAlıcı, Bülent
dc.contributor.authorAtaus, S.
dc.contributor.authorTuna, M. B.
dc.contributor.authorKılıç, M.
dc.date.accessioned2022-05-11T14:14:05Z
dc.date.available2022-05-11T14:14:05Z
dc.date.issued2010
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: The effects of the level and ratio changes in the trace elements have been reported previously in several diseases. The aim of this study was to determine whether those trace elements (Cu, Fe and Zn) can be used to distinguish among different histology grades of prostate cancer development and progression, and to assess the level changes of trace elements in serum and in tissues and copper-to-zinc and iron-to-zinc ratios in the serum and prostatic tissues of patients. Material and methods: 69 patients comprised of 23 patients with benign prostatic hypertrophy (BPH), 20 patients with malignant prostatic carcinoma (Malign Ca), 14 patients with low-grade prostatic intraepithelial neoplasia (LGPIN) and 12 patients with high grade prostatic intraepithelial neoplasia (HGPIN) diagnosed on basis of clinical profile, transrectal ultrasonography (TRUS) and histopathology, were included in this study. The levels of elements were determined by atomic absorption spectrophotometer. Results: The mean serum Cu levels in malign Ca were significantly higher than those seen in LGPIN, in HGPIN, and controls (p<0.001, p<0.01, p<0.001, respectively). The mean serum Cu/Zn ratios in malign Ca were significantly higher than those in BPH (p < 0.01), LGPIN (p < 0.01), HGPIN (p < 0.01), and controls (p<0.001). However, the mean serum Fe levels in controls were significantly lower than those in BPH, malign Ca, LGPIN and HGPIN (p<0.001 for each). The mean serum Fe/Zn ratio in controls were significantly lower than those in malign Ca and LGPIN (p < 0.001 for each). The mean tissue Cu levels in malign Ca were significantly higher than those in LGPIN (p < 0.01) and HGPIN (p < 0.05). However, the tissue Zn levels of malign Ca were significantly lower than those of BPH (p < 0.05), but similarly these differences were not statistically significant among malign Ca, LGPIN and HGPIN. The mean tissue Fe concentrations were significantly lower in LGPIN as compared to HGPIN (p<0.05). From Pearson correlation analysis, there were significant positive correlations between Cu/Zn and Fe/Zn ratios in serum, Fe/Zn in serum and Fe/Zn in tissue in HGPIN (r = 0.636, p < 0.05; r = 0.776, p < 0.01, respectively). Serum Cu/Zn was significantly positively correlated with serum Fe/Zn, tissue Cu/Zn and tissue Fe/Zn in malign Ca (r = 0.527, p < 0.05; r = 0.685, p < 0.01; r = 0.556, p<0.05, respectively). A significant positive correlation was also found between tissue Cu/Zn and tissue Fe/Zn in malign Ca (r = 0.639, p<0.01). Moreover, there was a significant positive correlation between serum Cu/Zn ratio and tissue Fe/Zn ratio in LGPIN (r = 0.755, p<0.01). However, there was a negativ correlation between tissue Cu/Zn ratio and serum Fe/Zn ratio in LG PIN (r = -0.695, p < 0.01). Conclusion: These findings indicate that changes of levels of Cu, Zn and Fe, and Cu/Zn and Fe/Zn ratios in the serum and/or tissue are influenced by the prostatic carcinoma development and progression. Therefore, further studies need to be performed to clarify the exact role of these disparities of trace elements that are rooted from and are affected by tumorigenesis or by the result of tumorigenesis.
dc.description.sponsorshipResearch Fund of Istanbul UniversityIstanbul University [BYP-2621/23062008]
dc.description.sponsorshipThe authors are grateful to Prof. Dr. Ilhan Onaran for his excellent technical assistance. This work was supported by The Research Fund of Istanbul University (Project BYP-2621/23062008). This study was partly presented at the 8th Ankara Urooncology Course, p 94, P 48, Ankara Turkey, November 28 December 2, 2007.
dc.identifier.endpage72
dc.identifier.issn0946-2104
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-77949660666
dc.identifier.scopusqualityN/A
dc.identifier.startpage65
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5777
dc.identifier.volume27
dc.identifier.wosWOS:000276260000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKızıler, Ali Rıza
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherDustri-Verlag Dr Karl Feistle
dc.relation.ispartofTrace Elements and Electrolytes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCu
dc.subjectFe
dc.subjectZn
dc.subjectCu/Zn
dc.subjectFe/Zn
dc.subjectprostatic carcinoma
dc.subjecthistology grade
dc.subjectCu-Zn Ratio
dc.subjectOxidative Stress
dc.subjectBreast-Cancer
dc.subjectZinc Levels
dc.subjectBenign
dc.subjectPlasma
dc.subjectCopper
dc.subjectSerum
dc.subjectCarcinoma
dc.titleMay the level and ratio changes of trace elements be utilized in identification of disease progression and grade in prostatic cancer?
dc.typeArticle

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