Carotid intima-media thickness and serum paraoxonase-1 activity in patients with Helicobacter pylori

Basit Öğe Kaydı
dc.authorid0000-0001-9584-0261
dc.authorscopusid36608599700
dc.authorscopusid55881189500
dc.authorscopusid6505680586
dc.authorscopusid36867089200
dc.authorscopusid8514414100
dc.authorscopusid57223054932
dc.authorscopusid37058172000
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.authorwosidTuran, Cemal/Q-7638-2019
dc.contributor.authorMete, Rafet
dc.contributor.authorOran, Mustafa
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorGüneş, H.
dc.contributor.authorTülübaş, Feti
dc.contributor.authorTuran, C.
dc.contributor.authorYıldırım, Oğuzhan
dc.date.accessioned2022-05-11T14:07:33Z
dc.date.available2022-05-11T14:07:33Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractAIM: To evaluate serum paraoxonase(PON)-1 activity and carotid intima-media thickness (CIMT) in patients with Cytotoxin-associated antigen(CagA)-positive and negative Helicobacter pylori strains. PATIENTS AND METHODS: The study group included a total of 134 individuals, of whom 103 were H. pylori positive, and 31 were H. pylori negative. Five biopsies were collected from each patient for histological examination: two from the antrum, two from the corpus, and one from the incisura angularis. The presence of H. pylori was determined using a modified Gram staining protocol. Peripheral blood was collected from each patient to determine levels of triglyceride, TC, HDL-cholesterol and LDL-cholesterol. IgG antibodies against CagA protein were analyzed by enzyme immunoassays. PON-1 activity was measured by colorimetric method. Carotid intima-media thickness and atherogenic plaques were measured using a grey scale color Doppler ultrasound. Data were analyzed by descriptive and inferential statistics. RESULTS: The right, the left and the mean CIMT were significantly higher in H. pylori (+) group versus H. pylori (-) group (p < 0.001 for all). However, the mean PON-1 concentration was significantly lower in H. pylori (+) group versus H. pylori (-) group (p < 0.001). The right, the left and the mean CIMT of CagA (+) group were significantly higher than that of CagA (-) group and controls, while PON-1 concentrations of CagA (+) group were significantly lower than that of CagA (-) group and controls (for all p = 0.0001). The right, the left and the mean CIMT of CagA (-) group were significantly higher than that of the control group, while the mean PON-1 concentration were significantly lower (for all p = 0.0001). CONCLUSIONS: Decreased PON-1 activity may be an etiopathogenetic factor in increased atherosclerosis in patients with H. pylori infection, especially in those infected with the CagA positive strain.
dc.identifier.endpage2889
dc.identifier.issn1128-3602
dc.identifier.issue21en_US
dc.identifier.pmid24254556
dc.identifier.scopus2-s2.0-84891756326
dc.identifier.scopusqualityQ2
dc.identifier.startpage2884
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5141
dc.identifier.volume17
dc.identifier.wosWOS:000328084800008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMete, Rafet
dc.institutionauthorOran, Mustafa
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorGüneş, H.
dc.institutionauthorTülübaş, Feti
dc.institutionauthorTuran, C.
dc.institutionauthorYıldırım, Oğuzhan
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCytotoxin-associated antigen
dc.subjectAtherosclerosis
dc.subjectCarotid intima-media thickness
dc.subjectParaoxonase-1
dc.subjectHelicobacter pylori strains
dc.subjectCoronary-Artery-Disease
dc.subjectHeart-Disease
dc.subjectAtherosclerotic Stroke
dc.subjectInfection
dc.subjectCaga
dc.subjectStrains
dc.subjectBurden
dc.subjectUlcer
dc.subjectRisk
dc.subjectPon1
dc.titleCarotid intima-media thickness and serum paraoxonase-1 activity in patients with Helicobacter pylori
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu