Selective and nonselective neuronal NOS inhibitors impair cognitive function in the three panel runway and passive avoidance tasks in rats

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dc.authorid0000-0002-7029-6519
dc.authorid0000-0001-7341-4907
dc.authorid0000-0001-5848-3680
dc.authorscopusid7003362092
dc.authorscopusid11440747800
dc.authorscopusid55125151300
dc.authorscopusid6603418006
dc.authorscopusid10638814800
dc.authorwosidARICIOGLU, FEYZA/AAR-5704-2020
dc.authorwosidAricioglu, Feyza/ABI-4003-2020
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidözer, cüneyt/AAR-6894-2020
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.contributor.authorUtkan, Tijen
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorÖzer, Cüneyt
dc.contributor.authorGacar, Nejat
dc.contributor.authorArıcıoğlu, Feyza
dc.date.accessioned2022-05-11T14:41:10Z
dc.date.available2022-05-11T14:41:10Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to compare the effects of both neuronal NOS (nNOS) and inducible NOS (iNOS) inhibitor 2-iminobiotin, with the more selective nNOS inhibitor N-omega-propyl-L-arginine (NPLA) and selective inducible NOS (iNOS) inhibitor aminoguanidine, on emotional learning, working memory and reference memory, by using three panel runway and passive avoidance paradigm in order to clarify the role of distinct isoforms of NOS in the regulation of learning and memory functions. NPLA and 2-iminobiotin significantly increased the number of errors and latency of working and reference memory performances of rats in three panel runway paradigm and impairs retention for the passive avoidance task. However, aminoguanidine did not affect cognitive functions in three panel runway and passive avoidance test. The effect of NPLA and 2-iminobiotin was reversed by pretreatment with a NOS substrate L-arginine. In conclusion, NPLA and 2-iminobiotin impaired cognitive functions in different kind of tasks used in this study and the effect of NPLA and 2-iminobiotin was found to be NO-dependent. Our results may confirm that nNOS plays the key role on emotional learning, working memory and reference memory in rats. (C) 2012 Elsevier Inc. All rights reserved.
dc.description.sponsorshipKocaeli UniversityKocaeli University [2007-2010/39]
dc.description.sponsorshipThis study was supported by a grant from Kocaeli University Research Fund (Project number: 2007-2010/39) and partly presented at 23rd ECNP Congress, August 28-September 1, 2010, Amsterdam, The Netherlands.
dc.identifier.doi10.1016/j.pbb.2012.02.020
dc.identifier.endpage519
dc.identifier.issn0091-3057
dc.identifier.issue4en_US
dc.identifier.pmid22405776
dc.identifier.scopus2-s2.0-84858717627
dc.identifier.scopusqualityQ1
dc.identifier.startpage515
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2012.02.020
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9091
dc.identifier.volume101
dc.identifier.wosWOS:000303951300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectN-omega-propyl L-Arginine
dc.subject2-iminobiotin
dc.subjectAminoguanidine
dc.subjectLearning
dc.subjectMemory
dc.subjectThree panel runway
dc.subjectPassive avoidance
dc.subjectNitric-Oxide Synthase
dc.subjectLong-Term Potentiation
dc.subjectPropyl-L-Arginine
dc.subjectMemory Formation
dc.subjectWorking-Memory
dc.subjectHypoxia
dc.subject7-Nitroindazole
dc.subjectHippocampus
dc.subjectIschemia
dc.subjectMaze
dc.titleSelective and nonselective neuronal NOS inhibitors impair cognitive function in the three panel runway and passive avoidance tasks in rats
dc.typeArticle

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