Clinical relevance of virulence genes in Helicobacter pylori isolates recovered from adult dyspeptic patients in Turkey

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dc.authoridAYDIN, Fuat/0000-0002-5467-011X
dc.authoridKarakaya, Emre/0000-0003-2390-6190
dc.authoridAkar, Mustafa/0000-0002-5589-2849
dc.authoridABAY, Secil/0000-0001-5599-7539
dc.authorwosidAkar, Mustafa/GSM-7072-2022
dc.contributor.authorAkar, Mustafa
dc.contributor.authorKayman, Tuba
dc.contributor.authorAbay, Seçil
dc.contributor.authorSolakoğlu, Tevfik
dc.contributor.authorKarakaya, Emre
dc.contributor.authorAydın, Fuat
dc.date.accessioned2023-04-20T08:01:18Z
dc.date.available2023-04-20T08:01:18Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose: Bacterial virulence factors play a major role in the pathogenesis of Helicobacter pylori infection. The aims of this study were to evaluate virulence genes in H. pylori isolates and to compare the presence of these genes and associated clinical pathologies. Methods: A total of 148 H. pylori isolates, recovered from adult dyspeptic patients, were used. The patients, from whom the isolates were obtained, were assigned to two groups by their endoscopic findings, which manifested as chronic gastritis or peptic ulcer. The presence of gastric atrophy and intestinal metaplasia was recorded for each patient, based on histopathological examination. Analyses of the virulence genes were performed by the polymerase chain reaction technique. Results: The patients had a mean age of 47 ?? 15 years and 86 (58%) of them were female. Based on endoscopic examination, 103 (69.6%) patients were diagnosed with chronic gastritis and 45 (30.4%) with peptic ulcer. Histopathological examination revealed intestinal metaplasia in 30 (20%) patients and gastric atrophy in 12 (8%) patients. The prevalence rates of cagA, cagE, iceA1, iceA2, and babA2 were determined to be 87%, 74%, 58%, 26%, and 95%, respectively. The most prevalent vacA alleles were s1/s1a (82%/97%) and the least prevalent allele was s2 (20%). A new vacA genotype (s1as1bs1c) was detected, for the first time, in 18 (12%) isolates. No significant difference was found between the patient groups with chronic gastritis and peptic ulcer for the prevalences of the virulence genes (p > 0.05). Furthermore, intestinal metaplasia and gastric atrophy showed no significant correlation with the virulence genes (p > 0.05). Conclusions: It is thoughted that H. pylori isolates with predominant cagA, cagE, VacA (s1, s1a), and babA2 virulence genes are associated with gastroduodenal diseases. However, there is no correlation between gastric premalignant lesions and virulence genes.
dc.identifier.doi10.1016/j.ijmmb.2021.12.018
dc.identifier.endpage262
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.issue2en_US
dc.identifier.pmid35031156
dc.identifier.scopus2-s2.0-85122632477
dc.identifier.scopusqualityQ3
dc.identifier.startpage258
dc.identifier.urihttps://doi.org/10.1016/j.ijmmb.2021.12.018
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10853
dc.identifier.volume40
dc.identifier.wosWOS:000798871200018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSolakoğlu, Tevfik
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofIndian Journal of Medical Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic Gastritis
dc.subjectDyspepsia
dc.subjectHelicobacter Pylori
dc.subjectTurkey
dc.subjectVirulence Genes
dc.subjectBaba2 Genotypes
dc.subjectGastroduodenal Diseases
dc.subjectVaca Genotypes
dc.subjectPeptic-Ulcer
dc.subjectCagpai Genes
dc.subjectCaga
dc.subjectIcea
dc.subjectAssociation
dc.subjectPrevalence
dc.subjectPathogenesis
dc.titleClinical relevance of virulence genes in Helicobacter pylori isolates recovered from adult dyspeptic patients in Turkey
dc.typeArticle

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