Bisphenol A as a risk factor for allergic rhinitis in children
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications Ltd
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Aim: Bisphenol-A (BPA) is an endocrine disrupting compound and may exacerbate or induce allergic diseases. To the best of our knowledge, there is little evidence regarding the effects of BPA exposure on allergic rhinitis (AR) in children. In the present study, we sought to examine whether exposure to BPA in children is associated with AR. Methods: This study was designed as a case controlled clinical study. 140 children diagnosed as allergic rhinitis and 140 healthy children as control group were recruited. BPA, interleukin-4, interleukin-13, total IgE and interferon-gamma levels were determined. Skin prick tests were performed in patient group. Total nasal symptom score and ARIA classification were used to predict disease severity. Results: Serum IL-4, IgE and BPA levels of children with allergic rhinitis were found to be significantly higher than the control group. BPA and IL-4 levels were significantly higher in moderate to severe-persistent group. There was a positive correlation between total nasal symptom scores and Bisphenol A levels in children with allergic rhinitis. Conclusions: The present study is the first to observe statistically significant relationship between BPA concentrations and allergic rhinitis in children. Also increased levels of BPA are associated with disease severity.
Description
Keywords
Endocrine disrupting chemicals, rhinitis, allergic, child, bisphenol A, Exposure, Diseases
Journal or Series
Human & Experimental Toxicology
WoS Q Value
Q3
Scopus Q Value
Q2
Volume
40
Issue
3
