Cardioprotective effects of fish omega-3 fatty acids on doxorubicin-induced cardiotoxicity in rats

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dc.authorscopusid26434076100
dc.authorscopusid24436194200
dc.authorscopusid8514414100
dc.authorscopusid6505680586
dc.authorscopusid37058172000
dc.authorscopusid6603048599
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorUygur, Ramazan
dc.contributor.authorAktaş, Cevat
dc.contributor.authorTülübaş, Feti
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorTopçu, Birol
dc.contributor.authorÖzen, Oğuz Aslan
dc.date.accessioned2022-05-11T14:07:35Z
dc.date.available2022-05-11T14:07:35Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate the protective effects of fish omega-3 (n-3) fatty acids on doxorubicin (DOX)-induced acute cardiotoxicity. A total of 24 rats were divided into three groups: control, DOX-treated, and DOX treated with fish n-3 fatty acids. Control group received 0.4 ml/kg/day of saline intragastrically. The rats in the fish n-3 fatty acid-pretreated group were given 400 mg/kg/day fish n-3 fatty acids for 30 days by intragastric intubation. To induce acute cardiotoxicity, DOX (30 mg/kg) was injected intraperitoneally by a single dose and the rats were killed after 48 h. DOX treatment caused severe damage in heart tissues. Disorganization of myocardial muscle fibers, myofibrillar loss, and cardiotoxic myocardial fibers with cytoplasmic vacuoles were seen. Fish n-3 fatty acid-treated rats showed an improved histological appearance in the DOX-treated group. Our data indicate a significant reduction in the activity of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling in cardiomyocytes of the DOX-treated group with fish n-3 fatty acids therapy. The DOX-treated with fish n-3 fatty acids group showed a significant decrease in malondialdehyde levels, and an increase in superoxide dismutase and glutathione peroxidase activities in comparison with the DOX-treated group. This study showed that fish n-3 fatty acids may be a suitable cardioprotector against acute toxic effects of DOX.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects UnitNamik Kemal University [NKUBAP.00.20.AR.11.05]
dc.description.sponsorshipThis study was supported by Namik Kemal University Scientific Research Projects Unit (Project Number: NKUBAP.00.20.AR.11.05).
dc.identifier.doi10.1177/0960327113493304
dc.identifier.endpage445
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue4en_US
dc.identifier.pmid24064909
dc.identifier.scopus2-s2.0-84896639712
dc.identifier.scopusqualityQ2
dc.identifier.startpage435
dc.identifier.urihttps://doi.org/10.1177/0960327113493304
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5152
dc.identifier.volume33
dc.identifier.wosWOS:000332923800009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUygur, Ramazan
dc.institutionauthorAktaş, Cevat
dc.institutionauthorTülübaş, Feti
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorTopçu, Birol
dc.institutionauthorÖzen, Oğuz Aslan
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectoxidative stress
dc.subjectapoptosis
dc.subjectDoxorubicin
dc.subjectcardiotoxicity
dc.subjectfish omega-3 fatty acids
dc.subjectEssential Fatty-Acids
dc.subjectInduced Cardiomyopathy
dc.subjectLipid-Peroxidation
dc.subjectOxidative Stress
dc.subjectHeart-Failure
dc.subjectCardiovascular Complications
dc.subjectSuperoxide-Dismutase
dc.subjectInduced Apoptosis
dc.subjectPhenethyl Ester
dc.subjectReactive Oxygen
dc.titleCardioprotective effects of fish omega-3 fatty acids on doxorubicin-induced cardiotoxicity in rats
dc.typeArticle

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