The diagnostic importance of matrix metalloproteinase-7 and nestin in gastrointestinal stromal tumors

Basit Öğe Kaydı
dc.authorid0000-0003-3981-6026
dc.authorscopusid8964575400
dc.authorscopusid55945180700
dc.authorscopusid17134802600
dc.authorscopusid26646261000
dc.authorscopusid15758639100
dc.authorscopusid15840512200
dc.authorscopusid55112859400
dc.authorwosidGökce, Aysun/AAD-3055-2022
dc.authorwosidÜnal, Tuba D/U-5375-2018
dc.authorwosidISIK, ARDA/H-4772-2019
dc.authorwosidSENOL, SERKAN/C-9858-2018
dc.authorwosidPeker, Kemal/AAK-2183-2021
dc.contributor.authorPeker, Kemal
dc.contributor.authorSayar, İlyas
dc.contributor.authorGelincik, İbrahim
dc.contributor.authorBulut, Gülay
dc.contributor.authorKökenek Ünal, Tuba Dilay
dc.contributor.authorŞenol, Serkan
dc.contributor.authorIşık, Arda
dc.date.accessioned2022-05-11T14:36:55Z
dc.date.available2022-05-11T14:36:55Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractBackground: The importance of the matrix metalloproteinase-7 (MMP-7) and nestin immunomarkers, C-kit proto-oncogene (CD117), and the efficiency of the Ki-67 proliferation index for gastrointestinal stromal tumors were evaluated. Material/Methods: This study was conducted by examining the microscope slides of 72 patients with gastrointestinal stromal tumors that were sent to the pathology laboratory between 2007 and 2012. Immunohistochemical staining for CD117, MMP-7, nestin, and marker of proliferation Ki-67 was performed. The correlations between the positive results for Ki-67, CD117, MMP-7, and nestin were evaluated relative to the tumor characteristics of size, localization, grade, cellular type, cellularity, cytology type, growth pattern, ulceration, necrosis, hemorrhage, invasion depth, and lymph node metastasis. Results: The tumor was localized in the stomach in 42 of the patients, the intestines in 19, the colon in 7, and the rectum in 4. Comparisons among the groups showed that MMP-7 was correlated with the tumor grade (p<0.001), cellularity (p<0.009), cytologic atypia (p<0.001), ulceration (p=0.002), necrosis (p<0.001), and tumor size (p=0.001). Nestin was correlated with the tumor grade (p=0.013), and tumor size (p=0.024). Correlations among CD117, MMP-7, nestin, and Ki-67 were examined. Nestin and Ki-67 were both significantly correlated with CD117 and MMP-7 [(r=0.279, p=0.018), (r=0.322, p=0.006), (r=0.386, p=0.001), (r=0.386, p=0.002)], respectively. Conclusions: MMP-7 and nestin may be beneficial as markers, given their sensitivity to gastrointestinal stromal tumors.
dc.identifier.endpage680
dc.identifier.issn1643-3750
dc.identifier.pmid24755685
dc.identifier.scopus2-s2.0-84899138711
dc.identifier.scopusqualityQ2
dc.identifier.startpage674
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8475
dc.identifier.volume20
dc.identifier.wosWOS:000334939200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGelincik, İbrahim
dc.language.isoen
dc.publisherInt Scientific Literature, Inc
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNestin
dc.subjectMatrix Metalloproteinase 7
dc.subjectGastrointestinal Stromal Tumors
dc.subjectClinical-Implications
dc.subjectExpression
dc.subjectBiology
dc.subjectCells
dc.subjectPrognosis
dc.titleThe diagnostic importance of matrix metalloproteinase-7 and nestin in gastrointestinal stromal tumors
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
8475.pdf
Boyut:
1.68 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu