Low serum Insulin Like Growth Factor-1 in patients with Stress Urinary Incontinence

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dc.authorid0000-0001-8617-3639
dc.authorid0000-0001-5254-2563
dc.authorid0000-0003-0679-2873
dc.authorid0000-0001-9115-7203
dc.authorid0000-0002-0553-3012
dc.authorscopusid24492292800
dc.authorscopusid25026476400
dc.authorscopusid56023692600
dc.authorscopusid36937882500
dc.authorscopusid35768988000
dc.authorscopusid33768003100
dc.authorscopusid8514414100
dc.authorwosidÖzcan, Levent/AAV-8512-2021
dc.authorwosidPolat, Emre Can/ABI-4703-2020
dc.authorwosiddursun, murat/C-6318-2019
dc.authorwosidErkoc, Mustafa/AAE-2641-2019
dc.contributor.authorÖzbek, Emin
dc.contributor.authorOtunçtemur, Alper
dc.contributor.authorŞahin, Süleyman
dc.contributor.authorÖzcan, Levent
dc.contributor.authorDursun, Murat
dc.contributor.authorPolat, Emrecan
dc.contributor.authorTülübaş, Feti
dc.contributor.authorÇekmen, Mustafa
dc.date.accessioned2022-05-11T14:42:06Z
dc.date.available2022-05-11T14:42:06Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI. Materials and Methods: All patients were evaluated for SUI and divided into two groups: 116 women with SUI and 76 women without SUI. Diagnosis of SUI was based on the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Levels of IGF-1 were measured in serum by enzyme-linked immunosorbent assay. The relationship between IGF-1 levels and SUI in patients was evaluated statisticaly. Results: The mean age of patients wiyh SUI was 49.9 +/- 8.6 and 48.7 +/- 7.8 in control group. Plasma IGF-1 levels were significantly lower in SUI than in control group (106.5 +/- 26.4 and 133.3 +/- 37.1ng/mL, respectively, P < 0.001). Body mass indexes were higher in women with SUI than women without SUI. Conclusion: In this study lower serum IGF-1 levels were found to be associated with SUI. Serum IGF-1 level appears to be a specific predictor of SUI, and it may be used in early prediction of SUI in female population.
dc.identifier.doi10.1590/S1677-5538.IBJU.2015.0453
dc.identifier.endpage792
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue4en_US
dc.identifier.pmid27564291
dc.identifier.scopus2-s2.0-84991080331
dc.identifier.scopusqualityQ2
dc.identifier.startpage787
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2015.0453
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9216
dc.identifier.volume42
dc.identifier.wosWOS:000391024000022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTülübaş, Feti
dc.language.isoen
dc.publisherBrazilian Soc Urol
dc.relation.ispartofInternational Braz J Urol
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUrinary Incontinence, Stress
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectInsulin-Like Growth Factor I
dc.subjectPeriurethral Connective-Tissue
dc.subjectPelvic Floor
dc.subjectBiochemical-Composition
dc.subjectWomen
dc.subjectCollagen
dc.subjectProlapse
dc.subjectExpression
dc.subjectContinent
dc.subjectIgf-1
dc.titleLow serum Insulin Like Growth Factor-1 in patients with Stress Urinary Incontinence
dc.typeArticle

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