The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture

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dc.authorid0000-0003-2420-8415
dc.authorscopusid8713588200
dc.authorscopusid6701406385
dc.authorscopusid36115580500
dc.authorscopusid56563019100
dc.authorscopusid23667114900
dc.authorscopusid6508166517
dc.authorscopusid56562993900
dc.authorwosidBAHTİYAR, NURTEN/D-6468-2019
dc.authorwosidCinemre, Hakan/AAD-7506-2021
dc.contributor.authorAydemir, Birsen
dc.contributor.authorAkdemir, Ramazan
dc.contributor.authorVatan, M. Bülent
dc.contributor.authorCinemre, Fatma Behice Serinkan
dc.contributor.authorCinemre, Hakan
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorÖğut, Selim
dc.date.accessioned2022-05-11T14:41:21Z
dc.date.available2022-05-11T14:41:21Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractChordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-alpha, IL-1 beta, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.
dc.description.sponsorshipUniversity of SakaryaSakarya University [2013-08-06-011]
dc.description.sponsorshipThis work was supported by the Research Fund of the University of Sakarya (project number: 2013-08-06-011). Also, this study was partly presented at 5th International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling and TRP Channels, Cell Membranes and Free Radical Research 6(1): pp 365-366, 9-12 Sep, Suleyman Demirel University, Isparta Turkey (2014) and Annual Meeting of the German Biophysicsal Society, p 88, 14-17 Sep, Lubeck University, Lubeck Germany (2014).
dc.identifier.doi10.1007/s12011-015-0307-6
dc.identifier.endpage186
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid25787827
dc.identifier.scopus2-s2.0-84941186629
dc.identifier.scopusqualityQ1
dc.identifier.startpage179
dc.identifier.urihttps://doi.org/10.1007/s12011-015-0307-6
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9153
dc.identifier.volume167
dc.identifier.wosWOS:000362282000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKızıler, Ali Rıza
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChordae tendineae rupture
dc.subjectZinc
dc.subjectSelenium
dc.subjectMidkine
dc.subjectInflammation
dc.subjectAngiogenesis
dc.subjectReduced glutathione
dc.subjectTrace-Elements
dc.subjectOxidative Stress
dc.subjectGrowth-Factor
dc.subjectDisease
dc.subjectAntioxidant
dc.subjectMechanisms
dc.subjectCadmium
dc.subjectHeart
dc.titleThe Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture
dc.typeArticle

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