Salivary and serum oxidative stress biomarkers and advanced glycation end products in periodontitis patients with or without diabetes: A cross-sectional study

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dc.authorid0000-0001-6327-3610
dc.authorid0000-0002-5054-1396
dc.authorid0000-0001-7083-0454
dc.authorscopusid56922265500
dc.authorscopusid56038788400
dc.authorscopusid56611642000
dc.authorscopusid35591227100
dc.authorscopusid13006777100
dc.authorscopusid53364360000
dc.authorscopusid6603010655
dc.authorwosidAltingoz, Sema Merve/AAI-1009-2021
dc.authorwosidTatakis, Dimitris/U-1084-2019
dc.authorwosidUnluturk, Ugur/A-1988-2016
dc.authorwosidKURGAN, Şivge/V-1549-2018
dc.authorwosidUyanik, Metin/L-7360-2015
dc.contributor.authorAltingoz, Sema Merve
dc.contributor.authorKurgan, Sivge
dc.contributor.authorÖnder, Canan
dc.contributor.authorSerdar, Muhittin A.
dc.contributor.authorÜnlütürk, Ugur
dc.contributor.authorUyanık, Metin
dc.contributor.authorGunhan, Meral
dc.date.accessioned2022-05-11T14:42:06Z
dc.date.available2022-05-11T14:42:06Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground Non-invasive methods for periodontitis diagnosis would be a clinically important tool. This cross-sectional study aimed to investigate the association between oxidative stress, glycation, and inflammation markers and periodontal clinical parameters in periodontitis and periodontally healthy patients with type 2 diabetes and corresponding systemically healthy controls. Material and methods Sixty-seven periodontally healthy (DM-H, n = 32) and periodontitis (DM-P, n = 35) patients with type 2 diabetes, and 54 systemically healthy periodontitis (H-P, n = 26) and periodontally healthy (H-H, n = 28) controls were included. Clinical periodontal parameters, body mass index, fasting glucose, hemoglobin A1c (HbA1c), along with saliva and serum 8-hydroxy-2 '-deoxyguanosine (8-OHdG), malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE), advanced glycation end products (AGE), AGE receptor (RAGE) and high sensitivity C-reactive protein (hsCRP) levels were recorded and analyzed. Results Salivary 8-OHdG levels were significantly higher in periodontitis compared to periodontally healthy patients, regardless of systemic status (P < 0.001). Salivary MDA levels were significantly higher in all disease groups compared to H-H group (P <= 0.004). Serum AGE levels were significantly higher in diabetic groups than systemically healthy groups (P < 0.001) and in H-P compared to H-H (P < 0.001). Bleeding on probing (BOP) and clinical attachment level (CAL) strongly correlated with salivary 8-OHdG and serum hsCRP (P < 0.001). In systemically healthy patients, salivary 8-OHdG was the most accurate marker to differentiate periodontitis from controls (AUC = 0.84). In diabetics salivary 4-HNE and RAGE were the most accurate (AUC = 0.85 for both). Conclusion Salivary 8-OHdG alone or in combination with 4-HNE, AGE and RAGE for diabetics, and salivary 8-OHdG alone or in combination with MDA and hsCRP for systemically healthy persons, could potentially serve as non-invasive screening marker(s) of periodontitis.
dc.description.sponsorshipAnkara University Scientific Research Projects Office, Ankara, Turkey [12B3334002]; Ankara University Department of Periodontology and Department of Endocrinology; Ohio State University Division of Periodontology
dc.description.sponsorshipThis study was supported by the Ankara University Scientific Research Projects Office, Ankara, Turkey (12B3334002). The authors declare that they have no conflicts of interest.; Ankara University Department of Periodontology and Department of Endocrinology; Ohio State University Division of Periodontology
dc.identifier.doi10.1002/JPER.20-0406
dc.identifier.endpage1285
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue9en_US
dc.identifier.pmid33277933
dc.identifier.scopus2-s2.0-85099051153
dc.identifier.scopusqualityQ1
dc.identifier.startpage1274
dc.identifier.urihttps://doi.org/10.1002/JPER.20-0406
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9224
dc.identifier.volume92
dc.identifier.wosWOS:000604418000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUyanık, Metin
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Periodontology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject4&#8208
dc.subjecthydroxy&#8208
dc.subject2&#8208
dc.subjectnonenal
dc.subject8&#8208
dc.subjecthydroxy&#8208
dc.subject2&#8208
dc.subjectdeoxyguanosine
dc.subjectdiabetes mellitus
dc.subjectoxidative stress
dc.subjectperiodontitis
dc.subjecttype 2
dc.subjectGingival Crevicular Fluid
dc.subjectC-Reactive Protein
dc.subjectLipid-Peroxidation Levels
dc.subjectTotal Oxidant Status
dc.subjectAssociation
dc.subjectDisease
dc.subjectMarkers
dc.subjectTherapy
dc.subjectRisk
dc.subject8-Hydroxy-2'-Deoxyguanosine
dc.titleSalivary and serum oxidative stress biomarkers and advanced glycation end products in periodontitis patients with or without diabetes: A cross-sectional study
dc.typeArticle

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