Serum chromogranin A levels are associated with the SYNTAX score in coronary artery disease

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dc.authoridAkyuz, Aydin/0000-0003-3304-4125
dc.authoridYILMAZ, AHSEN/0000-0002-2270-2965
dc.authoridKaplangoray, Mustafa/0000-0002-4297-1820
dc.authoridCELIKKOL, ALIYE/0000-0002-3799-4470
dc.authoridAydin, Cihan/0000-0002-1401-5727
dc.contributor.authorCelikkol, Aliye
dc.contributor.authorDemirkiran, Aykut
dc.contributor.authorAydin, Cihan
dc.contributor.authorAkyuz, Aydin
dc.contributor.authorKaplangoray, Mustafa
dc.contributor.authorYilmaz, Ahsen
dc.contributor.authorEfe, Muhammed Mucip
dc.date.accessioned2024-10-29T17:58:55Z
dc.date.available2024-10-29T17:58:55Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractOBJECTIVE: In this article, we investigated the association of chromogranin A with coronary artery disease.METHODS: Biochemical parameters and chromogranin A levels obtained from peripheral blood samples during coronary angiography were analyzed in 90 patients. Patients were classified into two groups, namely, SYNergy between PCI with TAXUS and Cardiac Surgery score >= 1 (n=45) and SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (n=45). This is a cross-sectional, prospective study. RESULTS: Serum chromogranin A levels were significantly higher in the group with SYNergy between PCI with TAXUS and Cardiac Surgery score >= 1 compared to the group with SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (1381.5 +/- 418.9 ng/mL and 1121.2 +/- 290.7 ng/mL, respectively; p=0.002). Serum chromogranin A levels were correlated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r=0.556, p<0.04). ROC analysis showed that the area under the curve for serum chromogranin A levels was 0.687 (p=0.007), and the best cutoff value of 1,131 ng/mL had a sensitivity of 67% and a specificity of 65% for the prediction of coronary artery disease.CONCLUSION: Serum chromogranin A levels were increased in coronary artery disease patients with SYNergy between PCI with TAXUS and Cardiac Surgery score >= 1. Increasing serum chromogranin A levels are proportional to the SYNergy between PCI with TAXUS and Cardiac Surgery score.KEYWORDS: Chromogranin A. Coronary artery disease. Hypertension.
dc.identifier.doi10.1590/1806-9282.20221254
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue4en_US
dc.identifier.pmid37075445
dc.identifier.scopus2-s2.0-85152979912
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20221254
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14559
dc.identifier.volume69
dc.identifier.wosWOS:000975206400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChromogranin A
dc.subjectCoronary artery disease
dc.subjectHypertension
dc.titleSerum chromogranin A levels are associated with the SYNTAX score in coronary artery disease
dc.typeArticle

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