miR-320a promotes p53-dependent apoptosis of prostate cancer cells by negatively regulating TP73-AS1 in vitro

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dc.authoridBozgeyik, Esra/0000-0002-8726-3182
dc.authorscopusid56497061100
dc.authorscopusid56468900300
dc.authorscopusid56221906000
dc.authorscopusid15764510600
dc.authorscopusid57203094952
dc.authorscopusid6504396778
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorArslan, Ahmet
dc.contributor.authorTemiz, Ebru
dc.contributor.authorBatar, Bahadır
dc.contributor.authorKoyuncu, İsmail
dc.contributor.authorTozkır, Hilmi
dc.date.accessioned2023-04-20T08:01:13Z
dc.date.available2023-04-20T08:01:13Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.description.abstractTP73 antisense RNA 1 (TP73-AS1) is an oncogenic long non-coding RNA that is activated in several types of cancers. It has been shown that the activity of TP73-AS1 is controlled by several miRNAs, but post -transcriptional mechanisms that regulate TP73-AS1 activity in prostate cancer remain highly elusive. Accordingly, in the present study, we aimed to determine the miRNAs that are involved in the regulation of TP73-AS1 in prostate cancer and to show the effects of these molecules on the malignant proliferation of prostate cancer cells. Remarkably, colony formation and cell migration were suppressed while cell cycle arrest and apoptosis were induced in prostate cancer cells overexpressing miR-200a and miR-320a. miR-200a and miR-320a were found to be upregulated in TP73-AS1 suppressed prostate cancer cells. Also, TP73-AS1 was shown to be downregulated following miR-200a and miR-320a overexpression. However, overexpression of miR-320a had no significant effect on the expression of TP73. Further analysis revealed that miR-320a induces p53-dependent apoptosis. Consequently, our findings indicate that miR-320a induces p53-dependent apoptosis by negatively regulating TP73-AS1 long non-coding RNA.(c) 2022 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.bbrc.2022.06.034
dc.identifier.endpage136
dc.identifier.issn0006-291X
dc.identifier.issn1090-2104
dc.identifier.pmid35760009
dc.identifier.scopus2-s2.0-85132536874
dc.identifier.scopusqualityQ1
dc.identifier.startpage130
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2022.06.034
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10799
dc.identifier.volume619
dc.identifier.wosWOS:000830257800020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorArslan, Ahmet
dc.institutionauthorTemiz, Ebru
dc.institutionauthorTozkır, Hilmi
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCancer
dc.subjectMir-200a
dc.subjectMir-320a
dc.subjectP53
dc.subjectProstate Cancer
dc.subjectTp73-As1
dc.subjectLong Noncoding Rna
dc.subjectProliferation
dc.subjectProgression
dc.subjectInvasion
dc.titlemiR-320a promotes p53-dependent apoptosis of prostate cancer cells by negatively regulating TP73-AS1 in vitro
dc.typeArticle

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