Alterations in bacterial spectrum and increasing resistance rates in isolated microorganisms from device-associated infections in an intensive care unit of a teaching hospital in Istanbul (2004-2010)

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dc.authorid0000-0002-4983-6613
dc.authorid0000-0002-0552-1337
dc.authorwosidInan, Asuman/D-5679-2014
dc.authorwosidSenbayrak, Seniha/AAC-4284-2019
dc.contributor.authorİnan, Asuman Şengöz
dc.contributor.authorÖzgültekin, Asu
dc.contributor.authorAkçay, Seniha Şenbayrak
dc.contributor.authorEngin, Derya Öztürk
dc.contributor.authorTuran, Güldem
dc.contributor.authorCeran, Nurgül
dc.contributor.authorErdem, İlknur
dc.date.accessioned2022-05-11T14:37:21Z
dc.date.available2022-05-11T14:37:21Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractThe aim of the present study was to determine the rate of device-associated infection (DAI) and the change in profiles and antimicrobial resistance patterns of the causative microorganisms in a medical-surgical intensive care unit (ICU), as well as to evaluate the effect of a new nationwide hospital infection control program (NHICP), which has been implemented in Turkey. In this study, 5,772 patients that were hospitalized for a total of 43,658 days acquired 1,321 DAIs, with an overall rate of 30.2% per 1,000 ICU days. Between 2004 (before the NHICP) and 2010, the incidence densities of catheter-associated urinary tract infection (CAUTI) decreased from 10.2 to 5.7 per 1,000 device-days (P < 0.0001), and central venous catheter-associated bloodstream infection (CVC-BSI) decreased from 5.3 to 2.1 per 1,000 device-days (P < 0.0001). However, ventilator-associated pneumonia increased from 27.0 to 31.5 per 1,000 device-days. Multidrug-resistant species rates increased from 5.8% to 76.6% (P < 0.0001) for Acinetobacter spp. and from 6.8% to 53.1% (P < 0.0001) for Pseudomonas aeruginosa. The extended-spectrum beta-lactamase-producing Enterobacteriaceae rate increased from 23.1% to 54.2% (P = 0.01); the vancomycin-resistance rate among Enterococcus spp. increased from 0% in 2004 to 12.5% in 2010 (P = 0.0003). In conclusion, while a significant decrease was achieved in the incidences of CAUTI and CVC-BSI, the NHICP was not completely effective in our ICU. The high incidence of DAI and the increasing prevalence of multidrug-resistant microorganisms indicate that further interventions are urgently needed.
dc.identifier.endpage151
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue2en_US
dc.identifier.pmid22446122
dc.identifier.scopus2-s2.0-84859077411
dc.identifier.scopusqualityQ2
dc.identifier.startpage146
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8668
dc.identifier.volume65
dc.identifier.wosWOS:000302526000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdem, İlknur
dc.language.isoen
dc.publisherNatl Inst Infectious Diseases
dc.relation.ispartofJapanese Journal of Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBlood-Stream Infection
dc.subjectLength-Of-Stay
dc.subjectNosocomial Infections
dc.subjectSurveillance
dc.subjectSystem
dc.titleAlterations in bacterial spectrum and increasing resistance rates in isolated microorganisms from device-associated infections in an intensive care unit of a teaching hospital in Istanbul (2004-2010)
dc.typeArticle

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