A case report of brain abscess caused by carbapenem- resistant Klebsiella pneumoniae

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dc.contributor.authorTunçkale, Tamer
dc.contributor.authorKavak, Çağlar
dc.contributor.authorŞafak, Birol
dc.contributor.authorGönen, Aysun
dc.contributor.authorErdem, İlknur
dc.date.accessioned2023-05-06T17:18:25Z
dc.date.available2023-05-06T17:18:25Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractThe treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains is difficult due to the limited antimicrobial options and high mortality. There are many reports on intracranial infections caused by CR-Kp, but only a few on brain abscesses caused by CR-Kp. Here, we present a case of brain abscess caused by CR-Kp successfully treated with combined antibiotics. A 26-year-old male patient was admitted to our hospital due to high fever and headache. His past medical history includes a surgical intervention due to an acute subdural hematoma, performed at an external healthcare center. After the current diagnosis of cerebral abscess, he underwent two surgeries. During the procedure, multiple cerebral abscesses were drained and capsulotomies were performed under ultrasound guidance. The combination of meropenem and vancomycin was started. The contents of the abscesses were sent to the microbiology and pathology laboratory. On the 3rd day of treatment, the medical team was informed that CR-Kp grew in an abscess culture. The patient's treatment was changed to meropenem + colistin + tigecycline. The patient developed electrolyte disturbances during the follow-up and this was considered an adverse effect of colistin. On the 41st day of treatment, colistin was discontinued, fosfomycin was added, and meropenem and tigecycline were maintained. Treatment was discontinued on the 68th day, when the patient was discharged. The general condition of the patient, who has been followed up for two years, is satisfactory. The treatment of CR-Kp infections should be individualized, and the pharmacokinetics and pharmacodynamics of antibiotics should be considered in each case.
dc.identifier.doi10.1590/S1678-9946202365023
dc.identifier.issn0036-4665
dc.identifier.issn1678-9946
dc.identifier.pmid36995876
dc.identifier.scopus2-s2.0-85151573496
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/S1678-9946202365023
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11817
dc.identifier.volume65
dc.identifier.wosWOS:000961565700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTunçkale, Tamer
dc.institutionauthorKavak, Çağlar
dc.institutionauthorŞafak, Birol
dc.institutionauthorGönen, Aysun
dc.institutionauthorErdem, İlknur
dc.language.isoen
dc.publisherInst Medicina Tropical Sao Paulo
dc.relation.ispartofRevista Do Instituto De Medicina Tropical De Sao Paulo
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKlebsiella pneumoniae
dc.subjectCarbapenem resistance
dc.subjectBrain abscesses
dc.subjectMeningitis
dc.titleA case report of brain abscess caused by carbapenem- resistant Klebsiella pneumoniae
dc.typeArticle

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