Characteristics of our hypoxemic COVID-19 pneumonia patients receiving corticosteroids and mortality-associated factors

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dc.authoridSöyler, Yasemin/0000-0002-0507-0767
dc.authoridsatici, celal/0000-0002-5457-9551
dc.authorscopusid56810869000
dc.authorscopusid55871277800
dc.authorscopusid57209092422
dc.authorscopusid57205707945
dc.authorscopusid21735417700
dc.authorscopusid55830557600
dc.authorscopusid56780380500
dc.authorwosidSöyler, Yasemin/AAF-8533-2021
dc.authorwosidOzdemir, Ozer/GQZ-6473-2022
dc.contributor.authorŞengül, Aysun
dc.contributor.authorMutlu, Pınar
dc.contributor.authorÖzdemir, Özer
dc.contributor.authorSatıcı, Celal
dc.contributor.authorTuran, Muzaffer Onur
dc.contributor.authorArslan, Sertaç
dc.contributor.authorMirici, Arzu
dc.contributor.authorMutlu, Levent Cern
dc.contributor.authorFazlioglu, Nevin
dc.date.accessioned2023-04-20T08:01:16Z
dc.date.available2023-04-20T08:01:16Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground COVID-19 is a disease associated with diffuse lung injury that has no proven effective treatment yet. It is thought that glucocorticoids may reduce inflammation-mediated lung injury, disease progression, and mortality. We aimed to evaluate our patient's characteristics and treatment outcomes who received corticosteroids for COVID-19 pneumonia. Methods We conducted a multicenter retrospective study and reviewed 517 patients admitted due to COVID-19 pneumonia who were hypoxemic and administered steroids regarding demographic, laboratory, and radiological characteristics, treatment response, and mortality-associated factors. Results Of our 517 patients with COVID-19 pneumonia who were hypoxemic and received corticosteroids, the mortality rate was 24.4% (n = 126). The evaluation of mortality-associated factors revealed that age, comorbidities, a CURB-65 score of >= 2, higher SOFA scores, presence of MAS, high doses of steroids, type of steroids, COVID-19 treatment, stay in the intensive care unit, high levels of d-dimer, CRP, ferritin, and troponin, and renal dysfunction were associated with mortality. Conclusion Due to high starting and average steroid doses are more associated with mortality, high-dose steroid administration should be avoided. We believe that knowing the factors associated with mortality in these cases is essential for close follow-up. The use of CURB-65 and SOFA scores can predict prognosis in COVID-19 pneumonia.
dc.identifier.doi10.1080/17476348.2022.2102480
dc.identifier.endpage958
dc.identifier.issn1747-6348
dc.identifier.issn1747-6356
dc.identifier.issue8en_US
dc.identifier.pmid35839345
dc.identifier.scopus2-s2.0-85135114550
dc.identifier.scopusqualityQ1
dc.identifier.startpage953
dc.identifier.urihttps://doi.org/10.1080/17476348.2022.2102480
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10840
dc.identifier.volume16
dc.identifier.wosWOS:000831157700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMutlu, Levent Cern
dc.institutionauthorFazlioglu, Nevin
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofExpert Review of Respiratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCovid-19
dc.subjectCorticosteroid
dc.subjectHypoxemia
dc.subjectMortality
dc.subjectPrognosis
dc.subjectRespiratory-Distress-Syndrome
dc.subjectDexamethasone
dc.subjectSeverity
dc.titleCharacteristics of our hypoxemic COVID-19 pneumonia patients receiving corticosteroids and mortality-associated factors
dc.typeArticle

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