Predictors of Outcome in Patients with Advanced Nonseminomatous Germ Cell Testicular Tumors

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dc.authorid0000-0001-9081-2405
dc.authorid0000-0002-3594-3661
dc.authorid0000-0003-4984-1049
dc.authorid0000-0002-9152-9887
dc.authorscopusid8666331800
dc.authorscopusid9632401100
dc.authorscopusid11540730500
dc.authorscopusid6701472672
dc.authorscopusid42660993000
dc.authorscopusid36112602800
dc.authorscopusid57198185356
dc.authorwosidAKSOY, SERCAN/J-1232-2013
dc.authorwosidseber, selcuk/T-9539-2019
dc.authorwosidAksoy, Sercan/S-2480-2019
dc.authorwosidCihan, Şener/AAW-1956-2021
dc.authorwosidÜrün, Yüksel/AAQ-3612-2020
dc.contributor.authorYetişyiğit, Tarkan
dc.contributor.authorBabacan, Nalan
dc.contributor.authorÜrün, Yüksel
dc.contributor.authorŞeber, Erdoğan Selçuk
dc.contributor.authorCihan, Sener
dc.contributor.authorArpacı, Erkan
dc.contributor.authorAlkış, Necati
dc.contributor.authorYalçın, Banu Çiçek
dc.date.accessioned2022-05-11T14:40:55Z
dc.date.available2022-05-11T14:40:55Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractBackground: Predictor factors determining complete response to treatment are still not clearly defined. We aimed to evaluate clinicopathological features, risk factors, treatment responses, and survival analysis of patient with advanced nonseminomatous GCTs (NSGCTs). Materials and Methods: Between November 1999 and September 2011, 140 patients with stage II and III NSGCTs were referred to our institutions and 125 patients with complete clinical data were included in this retrospective study. Four cycles of BEP regimen were applied as a first-line treatment. Salvage chemotherapy and/or high-dose chemotherapy (HDCT) with autologous stem cell transplantation were given in patients who progressed after BEP chemotherapy. Post-chemotherapy surgery was performed in selected patients with incomplete radiographic response and normal tumor markers. Results: The median age was 28 years. For the good, intermediate and poor risk groups, compete response rates (CRR) were, 84.6%, 67.9% and 59.4%, respectively. Extragonadal tumors, stage 3 disease, intermediate and poor risk factors, rete testis invasion were associated with worse outcomes. There were 32 patients (25.6%) with non-CR who were treated with salvage treatment. Thirty-one patients died from GCTs and 94% of them had stage III disease. Conclusions: Even though response rates are high, some patients with GCTs still need salvage treatment and cure cannot be achieved. Non-complete response to platinium-based first-line treatment is a negative prognostic factor. Our study confirmed the need for a prognostic and predictive model and more effective salvage approaches.
dc.identifier.doi10.7314/APJCP.2014.15.2.831
dc.identifier.endpage835
dc.identifier.issn1513-7368
dc.identifier.issue2en_US
dc.identifier.pmid24568504
dc.identifier.scopus2-s2.0-84894642571
dc.identifier.scopusqualityQ3
dc.identifier.startpage831
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.2.831
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8972
dc.identifier.volume15
dc.identifier.wosWOS:000332517500051
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYetişyiğit, Tarkan
dc.institutionauthorYalçın, Banu Çiçek
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdvanced disease
dc.subjectgerm cell tumor
dc.subjectnonseminomatous germ cell tumor
dc.subjectprognostic factors
dc.subjectCouncil European Organization
dc.subjectLymph-Node Dissection
dc.subjectClinical Stage-I
dc.subjectPrognostic-Factors
dc.subjectRandomized-Trial
dc.subjectPhase-Iii
dc.subjectConsensus Conference
dc.subjectEmbryonal Carcinoma
dc.subjectDose Cisplatin
dc.subjectCancer
dc.titlePredictors of Outcome in Patients with Advanced Nonseminomatous Germ Cell Testicular Tumors
dc.typeArticle

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