Does the serotonin receptor gene (rs6313 and rs6314) polymorphism have a role in suicidal attempts?

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dc.authorid0000-0001-9132-2424
dc.authorscopusid56237417100
dc.authorscopusid57188850107
dc.authorscopusid23009082100
dc.authorscopusid56236824600
dc.authorscopusid56221906000
dc.authorscopusid56010328600
dc.authorscopusid56468900300
dc.authorwosidTemiz, Ebru/AAI-2347-2019
dc.authorwosidakbaba, murat/AAG-7772-2020
dc.authorwosidTemiz, Ebru/ABF-6573-2021
dc.authorwosidKUL, SEVAL/AAG-7687-2020
dc.contributor.authorAtan, Yusuf
dc.contributor.authorAkbaba, Murat
dc.contributor.authorKul, Seval
dc.contributor.authorTataroğlu, Zekeriya
dc.contributor.authorTemiz, Ebru
dc.contributor.authorNacarkahya, Gülper
dc.contributor.authorArslan, Ahmet
dc.date.accessioned2022-05-11T14:42:07Z
dc.date.available2022-05-11T14:42:07Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractSuicide is an important public health problem. The aim of the present study is to determine the incidence of serotonin receptor gene polymorphisms (rs6313 and rs6314) in patients with a history of suicide attempt by blood sampling and to evaluate whether a causal relation exists between gene polymorphisms and suicide. After obtaining the necessary approvals for the study, we included 178 patients with attempted suicide history admitted to the emergency room between December 14, 2016 and July 31, 2016; 174 control subjects were also included. The blood samples were tested for rs6313 and rs6314 polymorphisms. Among the 178 cases with attempted suicide history, 116 (65.2%) were females and 62 (35.8%) were males. With regard to rs6313 polymorphisms in the case group, 40 cases had AA genotype, 99 had AG genotype, and 39 had GG genotype. In the control group, 38 subjects had AA genotype, 91 had AG genotype, and 45 had GG genotype. With regard to rs6314 polymorphisms, 176 cases in the case group had AG genotype and two cases had GG genotype in the case group, whereas 171 subjects in the control group had AG genotype and three subjects had GG genotype in the control group. The present study did not find any significant association between the incidence of rs6313 and rs6314 polymorphisms and suicidal behavior.
dc.identifier.doi10.1016/j.jflm.2018.03.006
dc.identifier.endpage36
dc.identifier.issn1752-928X
dc.identifier.issn1532-2009
dc.identifier.pmid29529493
dc.identifier.scopus2-s2.0-85043226856
dc.identifier.scopusqualityQ1
dc.identifier.startpage32
dc.identifier.urihttps://doi.org/10.1016/j.jflm.2018.03.006
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9235
dc.identifier.volume56
dc.identifier.wosWOS:000432777300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorArslan, Ahmet
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofJournal of Forensic and Legal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSuicide
dc.subjectrs6313
dc.subjectrs6314
dc.subjectSerotonin receptor gene polymorphism
dc.subjectTryptophan-Hydroxylase
dc.subjectTransporter Gene
dc.subjectFamily-History
dc.subjectBinding-Sites
dc.subjectBehavior
dc.subjectAssociation
dc.subjectSchizophrenia
dc.subjectHtr2a
dc.titleDoes the serotonin receptor gene (rs6313 and rs6314) polymorphism have a role in suicidal attempts?
dc.typeArticle

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