Contribution of neutrophil/lymphocyte ratio to the diagnostic efficiency of computed tomography and polymerase chain reaction in COVID-19 patients

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dc.authorid0000-0001-5879-7858
dc.authorwosidOrun, Serhat/AAB-2040-2020
dc.contributor.authorÖrün, Serhat
dc.contributor.authorErdem, Mustafa Numan
dc.date.accessioned2022-05-11T14:37:02Z
dc.date.available2022-05-11T14:37:02Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractBackground: 6.5% of the country's population was diagnosed with COVID-19 disease. Computed tomography scanning and polymerase chain reaction tests are considered reliable methods for the detection of COVID-19. However, the specificity and reliability of polymerase chain reaction tests and ground-glass opacity (GGO) on thorax computed tomography images in diagnosing COVID-19 are still being disputed. Our aim was to compare the neutrophil/lymphocyte ratio, whose efficiency in differentiating between viral and bacterial infections has previously been studied, with computed tomography and polymerase chain reaction for COVID-19 diagnosis. Materials and methods: This was a retrospective study that included patients treated in a tertiary care hospital emergency service pandemic polyclinic between 14 March and 1 June 2020. The neutrophil/lymphocyte ratios of patients with polymerase chain reaction tests and ground-glass opacities on computed tomography were calculated. The neutrophil/lymphocyte ratios of polymerase chain reaction-negative patients with computed tomography images were compared with the neutrophil/lymphocyte ratios of polymerase chain reaction-positive patients with computed tomography images. Results: A total of 631 patients were included in this study. Thorax computed tomography scans were obtained from all patients. The mean neutrophil/lymphocyte ratio of patients with ground-glass opacities was 3.50 +/- 2.12, whereas that of patients without ground-glass opacities was 2.90 +/- 2.01. This difference was also statistically significant. Polymerase chain reaction swab samples were obtained from 282 patients (44.7%). The mean neutrophil/lymphocyte ratio of polymerase chain reaction-positive patients was 2.38 +/- 1.02, whereas that of polymerase chain reaction-negative patients was 3.97 +/- 2.25. The difference was statistically significant. Conclusion: Many studies are undoubtedly required to determine the efficiency of the neutrophil/lymphocyte ratio in COVID-19 diagnosis. However, we postulate that evaluating the neutrophil/lymphocyte ratio along with computed tomography and polymerase chain reaction can assist in the diagnosis of patients.
dc.identifier.doi10.1177/20503121211046416
dc.identifier.issn2050-3121
dc.identifier.scopus2-s2.0-85115078637
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1177/20503121211046416
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8539
dc.identifier.volume9
dc.identifier.wosWOS:000702271900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖrün, Serhat
dc.institutionauthorErdem, Mustafa Numan
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofSage Open Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectneutrophil
dc.subjectlymphocyte ratio
dc.subjectground-glass opacity
dc.subjectthorax computed tomography
dc.subjectPneumonia
dc.titleContribution of neutrophil/lymphocyte ratio to the diagnostic efficiency of computed tomography and polymerase chain reaction in COVID-19 patients
dc.typeArticle

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