The Protective Effects of Kefir in Aspirin-Induced Gastric Mucosal Damage: An Experimental Study

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dc.contributor.authorAcartürk, Gürsel
dc.contributor.authorŞenol, Altuğ
dc.contributor.authorAkın, Mete
dc.contributor.authorSütçü, Recep
dc.contributor.authorŞahin, Önder
dc.contributor.authorİşler, Mehmet
dc.date.accessioned2022-05-11T14:36:55Z
dc.date.available2022-05-11T14:36:55Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractAims: Aspirin has a side effect of mucosal damage even at low doses. The aim of the present study was to investigate the efficacy of kefir in the prevention of gastric damage produced by aspirin. Materials and methods: In the present study, 32 male Wistar-Albino rats were divided into four equal groups. First group (Control) and 2nd group (Aspirin) were administered 2 ml serum physiologic for seven days. Third group (Kefir) and 4th group (Kefir + Aspirin) were administered 2 ml kefir solution instead of serum physiologic. On the eight day, aspirin and Kefir + Aspirin groups were administered 200 mg/kg aspirin, three hours before being sacrificed. All stomach mucosa was examined and mucosal damage scores were evaluated. Results: In Kefir + Aspirin group, macroscopic damage score was higher than Control (P=0.002) and Kefir (P=0.028) groups, and lower than Aspirin group (P=0.005). Histological damage scores in Kefir + Aspirin group were similar to those in control and kefir groups and significantly lower than Aspirin group (P<0.001). Conclusion: It was established that kefir prevents aspirin-induced gastric damage in experimental model.
dc.identifier.endpage879
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84903485177
dc.identifier.scopusqualityN/A
dc.identifier.startpage875
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8477
dc.identifier.volume30
dc.identifier.wosWOS:000344634300022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞahin, Önder
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAspirin
dc.subjectkefir
dc.subjectmucosal damage
dc.subjectprobiotic
dc.subjectHelicobacter-Pylori Eradication
dc.subjectLactic-Acid Bacteria
dc.subjectLactobacillus-Johnsonii
dc.subjectFermented Milk
dc.subjectHumans
dc.subjectTherapy
dc.subjectCulture
dc.subjectYogurt
dc.subjectLa1
dc.titleThe Protective Effects of Kefir in Aspirin-Induced Gastric Mucosal Damage: An Experimental Study
dc.typeArticle

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