Effects of chronic low- and high-dose ethanol intake on the nitrergic relaxations of corpus cavernosum and penile nitric oxide synthase in the rabbit

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dc.authorid0000-0003-0895-3490
dc.authorid0000-0001-7341-4907
dc.authorid0000-0002-9227-365X
dc.authorid0000-0001-5848-3680
dc.authorid0000-0002-8472-0261
dc.authorscopusid23991887300
dc.authorscopusid11440747800
dc.authorscopusid7003362092
dc.authorscopusid35331721100
dc.authorscopusid6603418006
dc.authorscopusid7003713314
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.authorwosidYazır, YUSUFHAN/F-7289-2018
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidCelikyurt, Ipek Komsuoglu/F-7363-2018
dc.authorwosidSARIOĞLU, YUSUF/J-2592-2018
dc.contributor.authorYazır, Y.
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorUtkan, Tijen
dc.contributor.authorKomşuoğlu Çelikyurt, I.
dc.contributor.authorGacar, Nejat
dc.contributor.authorSarıoğlu, Y.
dc.date.accessioned2022-05-11T14:41:10Z
dc.date.available2022-05-11T14:41:10Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractEpidemiological evidence showed that chronic ethanol consumption is a major risk factor in the development of impotence. The present study investigated the effects of carbachol-, electrical field stimulation (EFS)-, sodium nitroprusside (SNP)- and papaverine-induced relaxant responses in the isolated corpus cavernosum tissues from rabbits submitted to an 12-week course of chronic low (5% v/v) or high ethanol intake (30% v/v). Increased carbachol- and EFS-induced relaxant responses but not SNP and papaverine, were observed in low ethanol-fed rabbits compared with controls. However, impaired carbachol- and EFS-induced relaxant responses were observed in high ethanol-fed rabbits compared with control rabbits. There were no significant differences in SNP- and papaverine-induced relaxant responses between control and high ethanol-fed rabbits. In addition, decreased neuronal nitric oxide synthase (nNOS) and endothelial NOS (eNOS) immunoreactivity in penile tissue were found in high ethanol-fed rabbits, but increased the immunoreactivity in low ethanol-fed group, compared with control group. These results suggest that alterations in nitric oxide (NO) production within the cavernous tissue in the high ethanol-fed rabbits are, at least in part, responsible for the erectile dysfunction.
dc.description.sponsorshipKocaeli University Research FundKocaeli University [200319]
dc.description.sponsorshipThis study was supported by a grant from Kocaeli University Research Fund (Project number: 200319). Research Foundation had no further role in the study design, in the collection, analysis and interpretation of data, in the writing of the report and in the decision to submit the paper for publication.
dc.identifier.doi10.1038/ijir.2012.14
dc.identifier.endpage190
dc.identifier.issn0955-9930
dc.identifier.issn1476-5489
dc.identifier.issue5en_US
dc.identifier.pmid22573232
dc.identifier.scopus2-s2.0-84866380589
dc.identifier.scopusqualityQ2
dc.identifier.startpage185
dc.identifier.urihttps://doi.org/10.1038/ijir.2012.14
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9089
dc.identifier.volume24
dc.identifier.wosWOS:000309037400004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofInternational Journal of Impotence Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectalcohol consumption
dc.subjectcarbachol
dc.subjectcorpus cavernosum
dc.subjectimpotence
dc.subjectnitric oxide
dc.subjectEndothelium-Dependent Relaxation
dc.subjectModerate Alcohol-Consumption
dc.subjectSmooth-Muscle
dc.subjectResponses
dc.subjectRisk
dc.subjectRat
dc.subjectTestosterone
dc.subjectAcetaldehyde
dc.subjectReactivity
dc.subjectMortality
dc.titleEffects of chronic low- and high-dose ethanol intake on the nitrergic relaxations of corpus cavernosum and penile nitric oxide synthase in the rabbit
dc.typeArticle

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