Association of lower serum irisin levels with diabetes mellitus: Irrespective of coronary collateral circulation, and syntax score

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dc.contributor.authorAkyüz, Aydın
dc.contributor.authorMert, Beysim
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorEfe, Muhammet Mucip
dc.contributor.authorAykaç, Hüseyin
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:10:13Z
dc.date.available2022-05-11T14:10:13Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Irisin is a myokine thought to be involved in the pathophysiological process of atherosclerosis with its' cardiovascular protective effects. Patients with diabetes mellitus (DM) have lower levels of irisin. Therefore, we investigated whether there is a connection between irisin, DM, coronary collateral circulation (CCC), and SYNTAX scores representing coronary artery disease (CAD) severity. METHODS: This study evaluated 86 patients who have at least one epicardial coronary artery with chronic total occlusion. We included Rentrop 0-1 into the poor CCC group (n=45) and Rentrop 2-3 into the good CCC group (n=41) and measured serum irisin levels. RESULTS: Irisin levels did not differ (17585 [882-37741] pg/ml and (17504 [813-47683] pg/ml, p=0.772) between the two groups. Irisin levels were lower in patients with diabetes (n=41; 14485 [813-29398] pg/ml) than those without diabetes (n=45; 19724 [865-47683] pg/ml (p=0.002). Irisin was not correlated with SYNTAX scores. In multivariate analysis, DM (OR=0.463; CI: 0.184-0.783; p=0.012) was a negative predictor of good CCC development CONCLUSION: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity.
dc.identifier.doi10.14744/nci.2021.73669
dc.identifier.endpage614
dc.identifier.issn2148-4902
dc.identifier.issue6en_US
dc.identifier.startpage607
dc.identifier.trdizinid510463
dc.identifier.urihttps://doi.org/10.14744/nci.2021.73669
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5329
dc.identifier.volume8
dc.identifier.wosWOS:000744058200010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorMert, Beysim
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorEfe, Muhammet Mucip
dc.institutionauthorAykaç, Hüseyin
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCoronary circulation
dc.subjectdiabetes mellitus
dc.subjectirisin
dc.subjectAcute Myocardial-Infarction
dc.subjectAdipose-Tissue
dc.subjectSeverity
dc.subjectExercise
dc.subjectObesity
dc.subjectMuscle
dc.subjectFlow
dc.titleAssociation of lower serum irisin levels with diabetes mellitus: Irrespective of coronary collateral circulation, and syntax score
dc.typeArticle

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