The effects of isotretinoin on the ovarian reserve of females with acne

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dc.authorscopusid19933722100
dc.authorscopusid6506061779
dc.authorscopusid41862830000
dc.authorscopusid42661653300
dc.authorscopusid23968920100
dc.authorscopusid24779461500
dc.authorwosidKiran, Rebiay/AAS-3065-2020
dc.authorwosidAktürk, Aysun Şikar/AAS-3104-2020
dc.contributor.authorSıkar Aktürk, Aysun
dc.contributor.authorAbalı, Remzi
dc.contributor.authorYüksel, Mehmet Aytaç
dc.contributor.authorÇelik Güzel, Eda
dc.contributor.authorGüzel, Savaş
dc.contributor.authorKıran, Rebiay
dc.date.accessioned2022-05-11T14:10:13Z
dc.date.available2022-05-11T14:10:13Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThere are some side effects of isotretinoin in many organs. However, a study investigating the effects of isotretinoin on the human ovarian reserve has not been reported previously. The study was conducted to investigate possible effects of isotretinoin on ovarian reserve. Serum anti-Mullerian hormone (AMH) levels were measured at the beginning and at the end of isotretinoin treatment in 22 patients with acne and in 22 women without. The mean AMH level before treatment was 5.77 ng/mL in the study group and 3.79 ng/mL in the control group (p =0.008). Following treatment, the mean AMH level was 4.69 ng/mL in the study group. This mean AMH level after treatment was statistically lower than the AMH level before treatment (p= 0.012). There was no significant difference between the mean AMH level at the end of treatment and that of the control group (p= 0.20). The high level of pre-treatment AMH levels could be an evidence of hyperandrogenism in women with acne, even if they are not identified as having polycystic ovary syndrome (PCOS) or hyperandrogenism. Decrease in AMH levels following exposure to isotretinoin may suggest that it has a detrimental effect on the ovaries.
dc.identifier.doi10.3109/09513590.2013.860118
dc.identifier.endpage33
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue1en_US
dc.identifier.pmid24256373
dc.identifier.scopus2-s2.0-84890467064
dc.identifier.scopusqualityQ2
dc.identifier.startpage30
dc.identifier.urihttps://doi.org/10.3109/09513590.2013.860118
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5330
dc.identifier.volume30
dc.identifier.wosWOS:000329952900006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAbalı, Remzi
dc.institutionauthorÇelik Güzel, Eda
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcne
dc.subjectanti-Mullerian hormone
dc.subjectisotretinoin
dc.subjectovarian reserve
dc.subjectAnti-Mullerian Hormone
dc.subjectRetinoic Acid
dc.subjectMarker
dc.subjectWomen
dc.subjectCells
dc.subjectChemotherapy
dc.subjectMechanisms
dc.subjectFollicles
dc.subjectApoptosis
dc.subjectCancer
dc.titleThe effects of isotretinoin on the ovarian reserve of females with acne
dc.typeArticle

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