Status of High-risk Oncogenic Human Papillomavirus Subtypes Harbored in the Prepuce of Prepubertal Boys

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dc.authorid0000-0002-3068-4699
dc.authorid0000-0001-9427-777X
dc.authorscopusid6701810038
dc.authorscopusid55665526000
dc.authorscopusid33867696300
dc.authorscopusid6701904057
dc.authorscopusid12243570500
dc.authorwosidSavas, Murat/AAD-5570-2019
dc.authorwosidZEYREK, FADİLE YILDIZ/AAA-5368-2021
dc.authorwosidmordeniz, cengiz/A-5948-2017
dc.authorwosidciftci, Halil/ABF-3298-2020
dc.contributor.authorVerit, Ayhan
dc.contributor.authorZeyrek, Fadile Yıldız
dc.contributor.authorMordeniz, Cengiz
dc.contributor.authorÇiftçi, Halil
dc.contributor.authorSavaş, Murat
dc.date.accessioned2022-05-11T14:34:42Z
dc.date.available2022-05-11T14:34:42Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractOBJECTIVE To evaluate whether the high-risk human papillomavirus (HPV) subtypes that are strongly related to cervical cancer are harbored in the prepuce of the circumcised tissue of prepubertal boys in the period just before active sexual life. METHODS The present study enrolled 30 healthy boys (age range 4-11 years, mean age 8.1 +/- 1.6) who underwent a standard circumcision procedure, with hypospadias repair in 3 patients. All prepuceal samples were studied using real-time polymerase chain reaction and grouped according to HPV subtype prevalence as groups 1 (types 16 and 18), 2 (types 31, 33, 45, 52, and 58), and 3 (types 35, 39, 51, 56, 59, 66, and 68). RESULTS HPV DNA was reported in 25 (83.3%) of the 30 subjects. All samples showed a negative result for group 2. Although most of the positive findings were for group 3 (25 [83.3%] of 30), a positive result was reported for only 1 subject for group 1 (3.3%). CONCLUSION The results of the present study have shown that the prepuce harbored the rarest HPV types, including types 35, 39, 51, 56, 59, 66, and 68 in preadolescence boys with a high rate (83%). These findings are in contrast to the common knowledge of HPV prevalence in adults that points to the dominance of HPV subtypes 16 and 18. UROLOGY 80: 423-426, 2012. (c) 2012 Elsevier Inc.
dc.identifier.doi10.1016/j.urology.2012.02.049
dc.identifier.endpage426
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue2en_US
dc.identifier.pmid22554592
dc.identifier.scopus2-s2.0-84864590924
dc.identifier.scopusqualityQ2
dc.identifier.startpage423
dc.identifier.urihttps://doi.org/10.1016/j.urology.2012.02.049
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8062
dc.identifier.volume80
dc.identifier.wosWOS:000307244200060
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMordeniz, Cengiz
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMale Circumcision
dc.subjectCervical-Cancer
dc.subjectInfection
dc.subjectDna
dc.subjectMen
dc.titleStatus of High-risk Oncogenic Human Papillomavirus Subtypes Harbored in the Prepuce of Prepubertal Boys
dc.typeArticle

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