B-mode ultrasound assessment of carotid artery structural features in patients with normocalcaemic hyperparathyroidism

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dc.contributor.authorElbüken, Gülşah
dc.contributor.authorAydın, Cihan
dc.contributor.authorÖztürk, Beyza Olcay
dc.contributor.authorAykaç, Hüseyin
dc.contributor.authorTopçu, Birol
dc.contributor.authorZuhur, Sayid Shafi
dc.date.accessioned2023-05-06T17:18:25Z
dc.date.available2023-05-06T17:18:25Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractIntroduction: Normocalcaemic hyperparathyroidism is a condition first defined in 2008, characterized by normal se- rum calcium and high parathormone levels. Although normocalcaemic hyperparathyroidism is considered to have a milder clinical picture compared to asymptomatic primary hyperparathyroidism, recent studies have shown that it may be associated with osteoporosis, insulin resistance, metabolic syndrome, and cardiovascular risk factors. Considering that normo- calcaemic hyperparathyroidism may pose a cardiovascular risk in the setting of carotid atherosclerosis, we sought to examine the structural features of the carotid artery in patients with normocalcaemic hyperparathyroidism compared to a control group. Material and Methods: After excluding patients with hypertension, diabetes, and dyslipidaemia (other factors contributing to atheroscle- rosis), 37 (32 females, 5 males) patients with normocalcaemic hyperparathyroidism with a mean age of 51.2 +/- 8 (min: 32, max: 66) years and 40 controls (31 females, 9 males) with a mean age of 49.3 +/- 7.5 (min: 34, max: 64) years with normal serum albumin-corrected calcium and parathyroid hormone levels were included in the study. Structural features of the carotid artery including intima-media thickness (mean and maximum), lumen diameter, and the presence of plaque were assessed using B-mode ultrasound. Results: On ANCOVA analysis corrected for atherosclerotic factors (body mass index, waist circumference, fasting plasma glucose, serum cholesterol, lipid, and blood pressure), greater mean intima-media thickness was found in patients with normocalcaemic hyperparathyroidism than in controls (0.65 mm vs. 0.59 mm, respectively) (p = 0.023). Maximum ca- rotid intima-media thickness was also greater in patients with normocalcaemic hyperparathyroidism compared to controls (0.80 mm vs. 0.75 mm, respectively) (p = 0.044). The study groups did not show a significant difference in lumen diameter and the presence of carotid plaque. In addition, a negative correlation was found between parathormone (PTH) level and lumen diameter. Conclusion: The findings of this study show that as with asymptomatic primary hyperparathyroidism, normocalcaemic hyperparathy- roidism may be associated with increased cardiovascular risk by predisposing to atherosclerosis. (Endokrynol Pol 2023; 74 (1): 67-73)
dc.identifier.doi10.5603/EP.a2023.0010
dc.identifier.endpage73
dc.identifier.issn0423-104X
dc.identifier.issue1en_US
dc.identifier.pmid36847723
dc.identifier.scopus2-s2.0-85152051981
dc.identifier.scopusqualityQ3
dc.identifier.startpage67
dc.identifier.urihttps://doi.org/10.5603/EP.a2023.0010
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11819
dc.identifier.volume74
dc.identifier.wosWOS:000937849200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorElbüken, Gülşah
dc.institutionauthorAydın, Cihan
dc.institutionauthorÖztürk, Beyza Olcay
dc.institutionauthorAykaç, Hüseyin
dc.institutionauthorTopçu, Birol
dc.institutionauthorZuhur, Sayid Shafi
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofEndokrynologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectnormocalcaemic hyperparathyroidism
dc.subjectparathyroid hormone
dc.subjectcarotid intima-media thickness
dc.subjectmean intima-media thickness
dc.subjectmaximum intima-media thickness
dc.subjectlumen diameter
dc.subjectAsymptomatic Primary Hyperparathyroidism
dc.subjectIntima-Media Thickness
dc.subjectEndothelial Expression
dc.subjectAtherosclerosis Risk
dc.subjectWall Thickness
dc.subjectHeart-Disease
dc.subjectParathyroidectomy
dc.subjectManifestations
dc.subjectAbnormalities
dc.subjectProgression
dc.titleB-mode ultrasound assessment of carotid artery structural features in patients with normocalcaemic hyperparathyroidism
dc.typeArticle

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