Neurological soft signs might be endophenotype candidates for patients with deficit syndrome schizophrenia

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dc.authorid0000-0002-5770-344X
dc.authorscopusid29067508300
dc.authorscopusid34876196800
dc.authorscopusid27967486000
dc.authorscopusid25633859900
dc.authorscopusid55891056300
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.authorwosidBEYAZYUZ, MURAT/ABA-7934-2020
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorAkyol, Esra Soydaş
dc.contributor.authorBeyazyüz, Murat
dc.contributor.authorBaykal, Saliha
dc.contributor.authorKuloğlu, Murat
dc.date.accessioned2022-05-11T14:41:05Z
dc.date.available2022-05-11T14:41:05Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Schizophrenia is a chronic, disabling, disorder that affects approximately 1% of the population. The nature of schizophrenia is heterogeneous, and unsuccessful efforts to subtype this disorder have been made. Deficit syndrome schizophrenia (DS) is a clinical diagnosis that has not been placed in main diagnostic manuals. In this study, we aimed to investigate and compare neurological soft signs (NSS) in DS patients, non-deficit schizophrenia (NDS) patients, and healthy controls (HCs). We suggest that NSS might be an endophenotype candidate for DS patients. Methods: Sixty-six patients with schizophrenia and 30 HCs were enrolled in accordance with our inclusion and exclusion criteria. The patients were sub-typed as DS (n=24) and NDS (n=42) according to the Schedule for the Deficit Syndrome. The three groups were compared in terms of sociodemographic and clinical variables and total scores and subscores on the Physical and Neurological Examination for Soft Signs (PANESS). Following the comparison, a regression analysis was performed for predictability of total PANESS score and its subscales in the diagnosis of DS and NDS. Results: The groups were similar in terms of age, sex, and smoking status. The results of our study indicated that the total PANESS score was significantly higher in the DS group compared to the NDS and HC groups, and all PANESS subscales were significantly higher in the DS group than in the HC group. The diagnosis of DS was predicted significantly by total PANESS score (P<0.001, odds ratio =9.48, 95% confidence interval: 0.00-4.56); the synergy, graphesthesia, stereognosis, motor tasks, and ability to maintain posture subscales were found to be significant predictors. Conclusion: This study confirms that NSS were higher in patients with DS. In addition, we suggest that our results might support the notion of DS as a different and distinct type of schizophrenia. NSS might also be a promising candidate as an endophenotype for DS. However, large sampled, multicentric studies are needed to clarify the place of NSS as an endophenotype in DS.
dc.identifier.doi10.2147/NDT.S91170
dc.identifier.endpage2831
dc.identifier.issn1178-2021
dc.identifier.pmid26604767
dc.identifier.scopus2-s2.0-84946078996
dc.identifier.scopusqualityQ2
dc.identifier.startpage2825
dc.identifier.urihttps://doi.org/10.2147/NDT.S91170
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9058
dc.identifier.volume11
dc.identifier.wosWOS:000363783900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorBeyazyüz, Murat
dc.institutionauthorBaykal, Saliha
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiomarker
dc.subjectpsychosis
dc.subjectsign
dc.subjectclinical subtypes of schizophrenia
dc.subjectReliability
dc.subjectDisorders
dc.subjectSchedule
dc.subjectValidity
dc.titleNeurological soft signs might be endophenotype candidates for patients with deficit syndrome schizophrenia
dc.typeArticle

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