Upper urinary tract and urethral recurrences following radical cystectomy: review of risk factors and outcomes between centres with different follow-up protocols

Basit Öğe Kaydı
dc.authorid0000-0003-0455-9891
dc.authorid0000-0003-3647-0015
dc.authorscopusid54894362800
dc.authorscopusid23052928300
dc.authorscopusid7004014884
dc.authorscopusid16417344600
dc.authorscopusid6507566915
dc.authorscopusid11139575200
dc.authorscopusid7006135086
dc.authorwosidZlotta, Alexandre/K-8285-2015
dc.contributor.authorPerlis, Nathan
dc.contributor.authorTürker, Polat
dc.contributor.authorBostrom, Peter J.
dc.contributor.authorKuk, Cynthia
dc.contributor.authorMirtti, Tuomas
dc.contributor.authorKulkarni, Girish
dc.contributor.authorZlotta, Alexandre R.
dc.date.accessioned2022-05-11T14:36:57Z
dc.date.available2022-05-11T14:36:57Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractTo examine which patient-related and tumour-related characteristics predict upper urinary tract recurrence (UUTR) and urethral recurrence (UR) of bladder cancer post-radical cystectomy (RC). Secondary objective is to evaluate whether or not recurrence patterns are similar between two centres with different post-RC follow-up (F/U) protocols. A retrospective cohort study of 574 consecutive patients undergoing radical cystectomy for urothelial carcinoma of the bladder at two tertiary centres was performed. Clinicopathological factors associated with bladder cancer recurrence and patient-related outcomes, including time to recurrence and death, were collected. Risk factors for recurrences were examined using univariate and multivariable regression analyses. Likelihood of recurrence, time to recurrence, and survival were compared. There was a 3.7 % risk of UUTR (21/574) and a 3.6 % risk of UR (18/503) for the combined cohort at a median F/U of 45 months. When controlling for the effects of all variables modelled, female gender was a significant risk factor for UUT recurrence (OR 3.2, 95 % CI 1.0-9.5, p = 0.03) and prostatic urethral involvement was a significant risk factor for urethral recurrence (OR 7.8, 95 % CI 2.2-27.6, p = 0.001). UUTR were similar (p = 0.82) between Turku (8/205) and Toronto (12/369). Urethral recurrences trended (p = 0.06) towards being more common in Turku (9/151, 6.0 %) versus Toronto (9/352, 2.6 %), but no difference in overall survival was demonstrated between sites. The frequency of UUT and urethral recurrences post-cystectomy is relatively low and remained stable for the past 15 years. The ideal F/U protocol to maximize patient-survival remains unknown.
dc.identifier.doi10.1007/s00345-012-0905-2
dc.identifier.endpage167
dc.identifier.issn0724-4983
dc.identifier.issue1en_US
dc.identifier.pmid22810052
dc.identifier.scopus2-s2.0-84873197515
dc.identifier.scopusqualityQ1
dc.identifier.startpage161
dc.identifier.urihttps://doi.org/10.1007/s00345-012-0905-2
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8503
dc.identifier.volume31
dc.identifier.wosWOS:000314181900021
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTürker, Polat
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofWorld Journal of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectUrinary bladder neoplasm
dc.subjectCystectomy
dc.subjectNeoplasm recurrence
dc.subjectMortality
dc.subjectUrinary tract
dc.subjectTransitional-Cell Carcinoma
dc.subjectUrothelial Carcinoma
dc.subjectBladder-Cancer
dc.subjectSurveillance
dc.titleUpper urinary tract and urethral recurrences following radical cystectomy: review of risk factors and outcomes between centres with different follow-up protocols
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
8503.pdf
Boyut:
186.27 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu