The Association between Serum Endoglin Level and Coronary Collateral Vessel in Patients with Acute Coronary Syndromes

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dc.authorscopusid16315021800
dc.authorscopusid6505680586
dc.authorscopusid26532378600
dc.authorscopusid55810763400
dc.authorscopusid56503950500
dc.authorscopusid8514414100
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorDeğirmenci, Hasan
dc.contributor.authorErselcan, Kubilay
dc.contributor.authorTülübaş, Feti
dc.date.accessioned2022-05-11T14:14:04Z
dc.date.available2022-05-11T14:14:04Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: Previously, endoglin, also known as CD105, was shown to be related to angiogenesis. Objectives: The present study aimed to investigate the relationship between endoglin levels and development of Coronary Collateral Circulation (CCC) in patients with acute coronary syndrome. Patients and Methods: The study patients who underwent coronary angiography were divided into a poor collateral group (Group 1, N = 45) and a good collateral group (Group 2, N = 42), according to Rentrop classification. After recording the baseline characteristics, including age, Body Mass Index (BMI), systolic and diastolic blood pressures, smoking, history of hypertension, diabetes mellitus, and family history of Coronary Artery Disease (CAD), blood samples were taken for analysis of endoglin and other biochemical variables. The data were statistically analyzed using Mann-Whitney U test, independent sample t-test, chi-square test, ANOVA, Pearson's or Spearman's correlation tests, Receiver-Operating Characteristics (ROC) curve analysis, and multivariate logistic regression analysis. P values < 0.05 were considered as statistically significant. Results: Endoglin levels were significantly higher in Group 1 compared to Group 2 (13.6 +/- 3.8 vs. 10.2 +/- 2.9 ng/mL, P < 0.001). Serum endoglin levels were negatively correlated to age, C-Reactive Protein (CRP), and Low Density Lipoprotein-Cholesterol (LDL-C) levels. Moreover, ROC analysis (area under curve: 0.758; 95% CI: 0.655-0.844; P < 0.001) provided a cutoff value of <= 12.6 ng/mL for endoglin to predict good CCC with 85.7% sensitivity and 60% specificity. In multivariate logistic regression analysis, endoglin levels (OR = 0.97; 95% CI: 0.95 - 0.99; P = 0.002) and presence of total occlusion (OR = 2.51; 95% CI: 1.05 - 5.8; P = 0.036) were predictors of good CCC. Conclusions: Lower plasma endoglin levels were associated with better CCC development.
dc.identifier.endpage152
dc.identifier.issn2251-9130
dc.identifier.issn2251-9149
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84938604367
dc.identifier.scopusqualityQ4
dc.identifier.startpage145
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5771
dc.identifier.volume9
dc.identifier.wosWOS:000365702000003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorDeğirmenci, Hasan
dc.institutionauthorErselcan, Kubilay
dc.institutionauthorTülübaş, Feti
dc.language.isoen
dc.publisherShiraz Univ Medical Sciences, Cardiovascular Research Center
dc.relation.ispartofInternational Cardiovascular Research Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEndoglin
dc.subjectAngiogenesis
dc.subjectCollateral Circulation
dc.subjectCoronary Artery Disease
dc.subjectHereditary Hemorrhagic Telangiectasia
dc.subjectArtery Occlusion
dc.subjectGrowth-Factor
dc.subjectCirculation
dc.subjectAngiogenesis
dc.subjectCd105
dc.subjectMicrovessels
dc.subjectImmaturity
dc.subjectExpression
dc.subjectIschemia
dc.titleThe Association between Serum Endoglin Level and Coronary Collateral Vessel in Patients with Acute Coronary Syndromes
dc.typeArticle

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