The effects of hyperbaric oxygen application against cholestatic oxidative stress and hepatic damage after bile duct ligation in rats

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dc.authorid0000-0002-1347-8498
dc.authorscopusid6507986716
dc.authorscopusid7006356462
dc.authorscopusid16443917200
dc.authorscopusid37056003300
dc.authorscopusid7004285751
dc.authorscopusid36023238400
dc.authorscopusid6701389439
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorAyvaz, Süleyman
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAksu, Burhan
dc.contributor.authorŞahin, Sevtap Hekimoglu
dc.contributor.authorUzun, Hafize
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorPul, Mehmet
dc.date.accessioned2022-05-11T14:41:27Z
dc.date.available2022-05-11T14:41:27Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractBackground: The aim of this study was to evaluate the preventive and therapeutic potential of hyperbaric oxygen therapy (HBO) on the liver tissue against bile duct ligation (BDL)-induced oxidative damage and fibrosis in rats. Materials and methods: We divided 32 adult male Sprague Dawley rats into four groups: sham, sham plus HBO, BDL, and BDL plus HBO; each group contained eight animals. We placed the sham plus HBO and BDL plus HBO groups in an experimental hyperbaric chamber in which we administered pure oxygen at 2.5 atmospheres absolute 100% oxygen for 90 min on 14 consecutive days. Results: The application of BDL clearly increased the tissue malondialdehyde level, myeloperoxidase activity, and hydroxyproline content and decreased the antioxidant enzymes (superoxide dismutase and catalase activities) and glutathione level. Hyperbaric oxygen therapy treatment significantly decreased the elevated tissue malondialdehyde level, myeloperoxidase activity, and hydroxyproline content and increased the reduced superoxide dismutase and catalase activities and glutathione level in the tissues. The changes demonstrating the bile duct proliferation and fibrosis in expanded portal tracts include the extension of proliferated bile ducts into lobules, mononuclear cells, and neutrophil infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with HBO attenuated alterations in liver histology. Alpha smooth muscle actin, cytokeratinpositive ductular proliferation, and the activity of terminal deoxynucleotidyl transferase 2'-deoxyuridine, 5'-triphosphate nick end labeling in the BDL decreased with HBO treatment. Conclusions: The data indicate that HBO attenuates BDL-induced oxidative injury, hepatocytes damage, bile duct proliferation, and fibrosis. The hepatoprotective effect of HBO is associated with antioxidative potential. (C) 2013 Elsevier Inc. All rights reserved.
dc.description.sponsorshipTrakya University Research Center, Edirne, TurkeyTrakya University [2011-196]
dc.description.sponsorshipThis study was supported under Project TUBAB 2011-196 by the Trakya University Research Center, Edirne, Turkey.
dc.identifier.doi10.1016/j.jss.2012.12.036
dc.identifier.endpage155
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue1en_US
dc.identifier.pmid23462455
dc.identifier.scopus2-s2.0-84879075178
dc.identifier.scopusqualityQ1
dc.identifier.startpage146
dc.identifier.urihttps://doi.org/10.1016/j.jss.2012.12.036
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9184
dc.identifier.volume183
dc.identifier.wosWOS:000320599600026
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHBO
dc.subjectOxidative stress
dc.subjectImmunohistochemistry
dc.subjectTUNEL
dc.subjectBile duct ligation
dc.subjectBiliary-Obstructed Rats
dc.subjectLiver Fibrosis
dc.subjectMelatonin
dc.subjectReperfusion
dc.subjectApoptosis
dc.subjectInjury
dc.subjectCells
dc.subjectMechanisms
dc.subjectExpression
dc.subjectQuercetin
dc.titleThe effects of hyperbaric oxygen application against cholestatic oxidative stress and hepatic damage after bile duct ligation in rats
dc.typeArticle

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