The effects of vardenafil and pentoxifylline administration in an animal model of ischemic colitis

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dc.authorid0000-0003-2006-9198
dc.authorid0000-0001-6758-7289
dc.authorid0000-0001-8707-5301
dc.authorid0000-0001-9111-2734
dc.authorscopusid35791793300
dc.authorscopusid8431600000
dc.authorscopusid14042203500
dc.authorscopusid36134374200
dc.authorscopusid48460919300
dc.authorscopusid6603751762
dc.authorscopusid8688819200
dc.authorwosidDAS, Koray/AAD-8537-2021
dc.authorwosidSözen, Selim/ABA-6337-2020
dc.authorwosidirkorucu, oktay/AAL-7383-2020
dc.authorwosidAZİRET, MEHMET/I-5483-2014
dc.authorwosidCetinkunar, Suleyman/AFP-2813-2022
dc.contributor.authorAziret, Mehmet
dc.contributor.authorIrkorucu, Oktay
dc.contributor.authorReyhan, Enver
dc.contributor.authorErdem, Hasan
dc.contributor.authorDas, Koray
dc.contributor.authorÖzkara, Selvinaz
dc.contributor.authorDeger, Kamuran Cumhur
dc.contributor.authorSözen, Selim
dc.contributor.authorBali, İlhan
dc.date.accessioned2022-05-11T14:34:55Z
dc.date.available2022-05-11T14:34:55Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractOBJECTIVES: Vardenafil enhances dilatation of vascular smooth muscle and inhibits platelet aggregation. The purpose of this study was to evaluate the clinical effects of vardenafil and pentoxifylline administration in an experimental model of ischemic colitis. METHODS: Forty female Wistar albino rats weighing 250-300 g were randomized into five experimental groups (each with n = 8) as follows: 1) a sham group subjected to a sham surgical procedure and administered only tap water; 2) a control group subjected to a standardized surgical procedure to induce ischemic colitis and administered only tap water; 3) and 4) treatment groups subjected to surgical induction of ischemic colitis followed by the postoperative administration of 5 mg/kg or 10 mg/kg vardenafil, respectively; and 5) a treatment group subjected to surgical induction of ischemic colitis followed by postoperative administration of pentoxifylline at 50 mg/kg/day per day as a single dose for a 3-day period. All animals were sacrificed at 72 h post-surgery and subjected to relaparotomy. We scored the macroscopically visible damage, measured the ischemic area and scored histopathology to determine the severity of ischemia. Tissue malondialdehyde levels were also quantified. RESULTS: The mean Gomella ischemic areas were 63.3 mm(2) in the control group; 3.4 and 9.6 mm(2) in the vardenafil 5 and vardenafil 10 groups, respectively; and 3.4 mm(2) in the pentoxifylline group (p = 0.0001). The mean malondialdehyde values were 63.7 nmol/g in the control group; 25.3 and 25.6 nmol/g in the vardenafil 5 and vardenafil 10 groups, respectively; and 22.8 nmol/g in the pentoxifylline group (p = 0.0001). CONCLUSION: Our findings indicate that vardenafil and pentoxifylline are effective treatment options in an animal model of ischemic colitis. The positive clinical effects produced by these drugs are likely due to their influence on the hemodynamics associated with vascular smooth muscle and platelet functions.
dc.identifier.doi10.6061/clinics/2014(11)10
dc.identifier.endpage769
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.issue11en_US
dc.identifier.pmid25518035
dc.identifier.scopus2-s2.0-84920432204
dc.identifier.scopusqualityQ3
dc.identifier.startpage763
dc.identifier.urihttps://doi.org/10.6061/clinics/2014(11)10
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8138
dc.identifier.volume69
dc.identifier.wosWOS:000346477700010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSözen, Selim
dc.institutionauthorBali, İlhan
dc.language.isoen
dc.publisherHospital Clinicas, Univ Sao Paulo
dc.relation.ispartofClinics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIschemic Colitis
dc.subjectPDE-5 Inhibitors
dc.subjectPentoxifylline
dc.subjectVardenafil
dc.subjectSkin Flap Survival
dc.subjectReperfusion Injury
dc.subjectPulmonary-Artery
dc.subjectOxidative Stress
dc.subjectRat Model
dc.subjectSildenafil
dc.subjectInhibitor
dc.titleThe effects of vardenafil and pentoxifylline administration in an animal model of ischemic colitis
dc.typeArticle

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