Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats

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dc.authorscopusid26432848600
dc.authorscopusid7006356462
dc.authorscopusid24436194200
dc.authorscopusid36023238400
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErboğa, Mustafa
dc.date.accessioned2022-05-11T14:14:01Z
dc.date.available2022-05-11T14:14:01Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe present study was carried out to evaluate the neuroprotective effect of quercetin (QE) in protecting the cadmium (Cd)-induced neuronal injury in frontal cortex of rats. A total of 30 adult male Sprague-Dawley rats were randomly divided into three groups of 10 animals each: control, Cd treated and Cd treated with QE. The Cd-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in QE-treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection, during the study period. Rats were sacrificed at the end of the study and the frontal cortex tissues were removed for biochemical and histopathological investigation. To date, there is no available information on the effect of QE on neuronal injury after Cd exposure. Rats intoxicated with Cd for 30 days, significantly increased tissue malondialdehyde (MDA) levels and significantly decreased enzymatic antioxidants superoxide dismutase, glutathione peroxidase and catalase in the frontal cortex tissue. Administration of QE with Cd significantly diminished the levels of MDA and significantly elevated the levels of enzymatic antioxidants in the frontal cortex tissue. The histopathological studies in the brain of rats also supported that QE markedly reduced the Cd-induced histopathological changes and well preserved the normal histological architecture of the frontal cortex tissue. The caspase-3 immunopositivity was increased in degenerating neurons of the Cd group. Treatment with QE markedly reduced the immunoreactivity of degenerating neurons. In conclusion, the results of the current study suggest that QE may be beneficial in combating the Cd-induced neurotoxicity in the brain of rats. We believe that further preclinical research into the utility of QE may indicate its usefulness as a potential treatment for neurodegeneration after Cd exposure in rats.
dc.identifier.doi10.1177/0748233713486960
dc.identifier.endpage1115
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue12en_US
dc.identifier.pmid23645211
dc.identifier.scopus2-s2.0-84948659656
dc.identifier.scopusqualityQ3
dc.identifier.startpage1106
dc.identifier.urihttps://doi.org/10.1177/0748233713486960
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5746
dc.identifier.volume31
dc.identifier.wosWOS:000365745600006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜnsal, Cüneyt
dc.institutionauthorAktaş, Cevat
dc.institutionauthorErboğa, Mustafa
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCadmium
dc.subjectquercetin
dc.subjectoxidative stress
dc.subjectneuronal damage
dc.subjectneuronal apoptosis
dc.subjectrats
dc.subjectTraumatic Brain-Injury
dc.subjectSuperoxide-Dismutase
dc.subjectCortical-Neurons
dc.subjectIn-Vivo
dc.subjectGlutathione
dc.subjectNeurotoxicity
dc.subjectExpression
dc.subjectMetallothionein
dc.subjectNephrotoxicity
dc.subjectCytotoxicity
dc.titleRole of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats
dc.typeArticle

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