Quercetin ameliorates methotrexate-induced renal damage, apoptosis and oxidative stress in rats

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dc.authorscopusid36023238400
dc.authorscopusid24436194200
dc.authorscopusid56816914100
dc.authorscopusid55134339900
dc.authorscopusid36866111300
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorDönmez, Yeliz Bozdemir
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:09:57Z
dc.date.available2022-05-11T14:09:57Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: In the present study, the protective and therapeutic effects of quercetin (QE) on renal injury induced by methotrexate (MTX) have been examined. Materials and methods: A total of 24 male rats were divided into the following three groups: control group, MTX group, and MTX+QE group. Rats in MTX group received 20mg/kg of single dose of MTX, while those in MTX+QE group received 20mg/kg of single dose MTX, in addition to 15mg/kg of QE administered 30min prior to MTX and in the following 5-day period as a single daily dose. At the end of the experimental period, renal tissues were removed for histopathological and biochemical assessments. Results: Light microscopic examination showed a disruption of the renal structure in rats in MTX group in the form of tubular degeneration and dilation, with shedding of the tubular epithelial cells into the lumen. QE treatment was associated with less marked degenerative changes, with a similar histological appearance to that of controls. Furthermore, QE treatment resulted in decreased the number of apoptotic cells. Biochemical assessments showed significantly higher malondialdehyde (MDA) levels in MTX group as compared to control and MTX+QE groups. superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) levels showed a significant decrease in MTX group as compared to controls. However, QE significantly suppressed MDA level, compensated deficits in the anti-oxidant defenses [reduced SOD, GSH-Px, and CAT levels] in kidney tissue resulted from MTX administration. Conclusions: In conclusion, renal toxic effects of MTX may be alleviated by QE.
dc.identifier.doi10.3109/0886022X.2015.1074521
dc.identifier.endpage1497
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue9en_US
dc.identifier.pmid26338102
dc.identifier.scopus2-s2.0-84944165976
dc.identifier.scopusqualityQ2
dc.identifier.startpage1492
dc.identifier.urihttps://doi.org/10.3109/0886022X.2015.1074521
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5214
dc.identifier.volume37
dc.identifier.wosWOS:000369740900017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorAktaş, Cevat
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorDönmez, Yeliz Bozdemir
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectmethotrexate
dc.subjectnephrotoxicity
dc.subjectoxidative stress
dc.subjectquercetin
dc.subjectInduced Nephrotoxicity
dc.subjectAdenosine-Deaminase
dc.subjectDna-Damage
dc.subjectInjury
dc.subjectAcid
dc.subjectToxicity
dc.subjectProtects
dc.subjectKidney
dc.titleQuercetin ameliorates methotrexate-induced renal damage, apoptosis and oxidative stress in rats
dc.typeArticle

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