Protective effects of Urtica dioica L. on experimental testicular ischaemia reperfusion injury in rats

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dc.authorscopusid24436194200
dc.authorscopusid36023238400
dc.authorscopusid56659422100
dc.authorscopusid56755425900
dc.authorscopusid37058172000
dc.authorscopusid36866111300
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErbo?a, Mustafa
dc.contributor.authorFidanol Erboğa, Zeynep
dc.contributor.authorDönmez, Yeliz Bozdemir
dc.contributor.authorTopçu, Birol
dc.contributor.authorGürel, Aydın
dc.date.accessioned2022-05-11T14:10:16Z
dc.date.available2022-05-11T14:10:16Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractIn this study, it was aimed to examine the effects of Urtica dioica L. (UD) that has antioxidant feature in the experimental testicular I/R model in rats in terms of anti-apoptotic and antioxidative effects. In our study, 24 male rats were divided into three groups: control group, I/R group and I/R+UD (2mgkg(-1)) group. Seminiferous tubule calibre measurement, Johnson score, haematoxylin-eosin staining, proliferative cell nucleus antigen (PCNA) immunohistochemical staining and TUNEL as histopathological have been conducted. The structural deterioration in the testicular on I/R group has reduced after the treatment of UD. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end labelling (TUNEL), and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of UD-treated rats in the I/R group. The I/R+UD group showed a decrease in malondialdehyde levels and an increase in the activities of superoxide dismutase, catalase and glutathione peroxidase in comparison with the I/R group. It could be concluded that protective effects of UD on the I/R testicles are via reduction of histological damage, apoptosis, oxidative stress and lipid peroxidation.
dc.description.sponsorshipNamik Kemal University Research Center, Tekirdag, TurkeyNamik Kemal University [NKUBAP.00.20.AR.14.11]
dc.description.sponsorshipThis study was supported under Project NKUBAP.00.20.AR.14.11 by the Namik Kemal University Research Center, Tekirdag, Turkey.
dc.identifier.doi10.1111/and.12636
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue4en_US
dc.identifier.pmid27389487
dc.identifier.scopus2-s2.0-84978274910
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/and.12636
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5347
dc.identifier.volume49
dc.identifier.wosWOS:000398786300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAktaş, Cevat
dc.institutionauthorErbo?a, Mustafa
dc.institutionauthorFidanol Erboğa, Zeynep
dc.institutionauthorTopçu, Birol
dc.institutionauthorGürel, Aydın
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectischaemia and reperfusion
dc.subjecttestis-apoptosis-oxidative stress
dc.subjectUrtica dioica L
dc.subjectGerm-Cell Apoptosis
dc.subjectRenal Ischemia/Reperfusion Injury
dc.subjectLipid-Peroxidation
dc.subjectOxidative Stress
dc.subjectSpermatic Cord
dc.subjectDiabetic-Rats
dc.subjectAdult-Rat
dc.subjectTestis
dc.subjectTorsion
dc.subjectDamage
dc.titleProtective effects of Urtica dioica L. on experimental testicular ischaemia reperfusion injury in rats
dc.typeArticle

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