Association Between Genetic Variants of DNA Repair Genes and Coronary Artery Disease

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dc.authorid0000-0001-7960-9131
dc.authorscopusid6701839985
dc.authorscopusid36999889700
dc.authorscopusid36089765100
dc.authorscopusid8514414100
dc.authorscopusid14628108500
dc.authorscopusid56469237800
dc.authorscopusid35607960500
dc.authorwosidElitok, Ali/AAE-5404-2020
dc.authorwosidSeckin, Sule/AAE-2234-2020
dc.authorwosidTamer, Ayse Sule/AAD-9216-2020
dc.authorwosid/AAD-1662-2020
dc.authorwosidCakmakoglu, Bedia/G-9683-2017
dc.authorwosidDasdemir, Selcuk/AAE-2158-2020
dc.contributor.authorGökkuşu, Cahide
dc.contributor.authorÇakmakoğlu, Bedia
dc.contributor.authorDaşdemir, Selçuk
dc.contributor.authorTülübaş, Feti
dc.contributor.authorElitok, Ali
dc.contributor.authorTamer, Sule
dc.contributor.authorUmman, Berrin
dc.date.accessioned2022-05-11T14:42:05Z
dc.date.available2022-05-11T14:42:05Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractPolymorphisms in DNA repair genes may be associated with differences in the repair efficiency of DNA damage and may influence an individual's risk of atherosclerosis. Genetic research on coronary artery disease (CAD) has traditionally focused on investigation aimed at identifying disease-susceptibility genes. The aim of this study was to investigate the relationship between AP-endonuclease-1 (Asp148Glu), XRCC1 (Arg399Gln), XRCC3 (Thr241Met), XPD (Lys751Gln), XPG (Asp1104His), and hOGG1 (Ser326Cys), gene polymorphisms and the risk of developing CAD in a Turkish population. The study population consisted of 197 patients with acute coronary syndrome (ACS) with chronic CAD and 135 healthy subjects' age and sex matched. Gene polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism method. We demonstrated for the first time, a positive association of XRCC3 and hOGG1 DNA repair gene variants with CAD risk. XRCC3 Thr/Thr genotype and Thr allele frequencies were significantly increased in ACS and chronic CAD patients compared with the control group (p < 0.05). It was also observed that there is a protective role of XRCC3 Met alleles against both ACS and chronic CAD (p < 0.05). hOGG1 Cys alleles were found significantly higher in ACS patients than in the control group and carriers of the Cys allele had a 1.7-fold increased risk for ACS. In addition, we confirmed the association of XRCC3 Thr241Met and hOGG1 Ser326Cys gene variants with CAD by haplotype analysis. We found that CAD risk is associated with XRCC3 Thr: hOGG1 Cys haplotype, whereas XRCC3 Met: hOGG1 Ser haplotype was found to be protective against the disease. The preliminary results suggested that XRCC3 and hOGG1 genetic variants may be risk factors by affecting the enzyme's function that may lead to development of CAD.
dc.description.sponsorshipResearch Foundation of the University of IstanbulIstanbul University [UDP-17986/02082011]
dc.description.sponsorshipThis work was supported by the Research Foundation of the University of Istanbul (Project No. UDP-17986/02082011).
dc.identifier.doi10.1089/gtmb.2012.0383
dc.identifier.endpage313
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue4en_US
dc.identifier.pmid23368530
dc.identifier.scopus2-s2.0-84875647929
dc.identifier.scopusqualityQ3
dc.identifier.startpage307
dc.identifier.urihttps://doi.org/10.1089/gtmb.2012.0383
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9207
dc.identifier.volume17
dc.identifier.wosWOS:000316737300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTülübaş, Feti
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofGenetic Testing and Molecular Biomarkers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectXrcc3 Polymorphisms
dc.subjectDamage
dc.subjectXpd
dc.subjectSusceptibility
dc.subjectCapacity
dc.subjectErcc2
dc.subjectRisk
dc.subjectApe1
dc.titleAssociation Between Genetic Variants of DNA Repair Genes and Coronary Artery Disease
dc.typeArticle

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