Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea

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dc.authorid0000-0002-3535-5704
dc.authorid0000-0002-2270-2965
dc.authorid0000-0003-2112-4056
dc.authorscopusid54892706700
dc.authorscopusid8531050000
dc.authorscopusid26532378600
dc.authorscopusid7102765266
dc.authorscopusid56715752200
dc.authorscopusid55858591400
dc.authorscopusid55844573100
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorAydın, Murat
dc.contributor.authorBilir, Bülent
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorMalhotra, Atul
dc.date.accessioned2022-05-11T14:07:41Z
dc.date.available2022-05-11T14:07:41Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObstructive sleep apnea (OSA) is associated with increased cardiovascular (CV) morbidity and mortality. Endocan is a surrogate endothelial dysfunction marker that may be associated with CV risk factors. In this study, we tested whether serum endocan is a biomarker for OSA. Serum endocan levels were measured at baseline in 40 patients with OSA and 40 healthy controls and after 3 months of continuous positive airway pressure (CPAP) treatment in the patients with OSA. All participants were evaluated by full polysomnography. Flow-mediated dilatation (FMD) and carotid intima media thickness (cIMT) were measured in all participants. Endocan levels were significantly higher in patients with OSA than in healthy controls. After adjusting confounders, endocan was a good predictor of OSA. Endocan levels correlated with OSA severity (measured by the apnea-hypopnea index [AHI]). After 3 months of CPAP treatment, endocan levels significantly decreased. Endocan levels were significantly and independently correlated with cIMT and FMD after multiple adjustments. The cIMT and FMD also had significant and independent correlation with AHI. Endocan might be a useful marker for the predisposition of patients with OSA to premature vascular disease.
dc.description.sponsorshipNHLBI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01 HL085188, K24 HL093218, T32 HL134632, K24 HL132105] Funding Source: Medline; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01HL085188, K24HL093218, T32HL134632, K24HL132105] Funding Source: NIH RePORTER
dc.identifier.doi10.1177/0003319715590558
dc.identifier.endpage374
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue4en_US
dc.identifier.pmid26076702
dc.identifier.scopus2-s2.0-84959280313
dc.identifier.scopusqualityQ2
dc.identifier.startpage364
dc.identifier.urihttps://doi.org/10.1177/0003319715590558
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5176
dc.identifier.volume67
dc.identifier.wosWOS:000371305600011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAltıntaş, Nejat
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorAydın, Murat
dc.institutionauthorBilir, Bülent
dc.institutionauthorYılmaz, Ahsen
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofAngiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiomarkers
dc.subjectcarotid intima media thickness
dc.subjectendocan
dc.subjectflow-mediated dilatation
dc.subjectobstructive sleep apnea
dc.subjectPositive Airway Pressure
dc.subjectCell Specific Molecule-1
dc.subjectFlow-Mediated Dilation
dc.subjectC-Reactive Protein
dc.subjectMiddle-Aged Men
dc.subjectAdhesion Molecules
dc.subjectOxidative Stress
dc.subjectCardiovascular-Disease
dc.subjectHypertension
dc.subjectInflammation
dc.titleEffect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea
dc.typeArticle

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